2. Anti-infection Metabolic Enzyme/Protease
  3. Fungal Endogenous Metabolite
  4. Fumitremorgin B

Fumitremorgin B is a tremorgenic mycotoxin. Fumitremorgin B exhibits significant antifungal activities, with MICs of 6.25-50 μg/mL.

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Fumitremorgin B

Fumitremorgin B 構造式

CAS 番号 : 12626-17-4

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Fumitremorgin B 関連抗体

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製品説明

Fumitremorgin B is a tremorgenic mycotoxin. Fumitremorgin B exhibits significant antifungal activities, with MICs of 6.25-50 μg/mL[1][2][3].

IC50 & Target

fungal[3]
Cellular Effect
Cell Line Type Value Description References
HT-29 IC50
5 3
Compound: 8; FTM-B
Cytotoxicity against human HT-29 cells
Cytotoxicity against human HT-29 cells
[PMID: 27865702]
HeLa IC50
5 3
Compound: 8; FTM-B
Cytotoxicity against human HeLa cells
Cytotoxicity against human HeLa cells
[PMID: 27865702]
HeLa IC50
5 3
Compound: 8; FTM-B
Cytotoxicity against human HeLa cells
Cytotoxicity against human HeLa cells
[PMID: 27865702]
HT-29 IC50
5 3
Compound: 8; FTM-B
Cytotoxicity against human HT-29 cells
Cytotoxicity against human HT-29 cells
[PMID: 27865702]
Jurkat IC50
5 3
Compound: 8; FTM-B
Cytotoxicity against human Jurkat cells
Cytotoxicity against human Jurkat cells
[PMID: 27865702]
Jurkat IC50
5 3
Compound: 8; FTM-B
Cytotoxicity against human Jurkat cells
Cytotoxicity against human Jurkat cells
[PMID: 27865702]
MCF7 IC50
5 3
Compound: 8; FTM-B
Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
[PMID: 27865702]
MCF7 IC50
5 3
Compound: 8; FTM-B
Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
[PMID: 27865702]
PC-3 IC50
43.36 3
Compound: 574
Cytotoxicity against human PC-3 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
Cytotoxicity against human PC-3 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
[PMID: 38181652]
U-937 IC50
14.12 3
Compound: 574
Cytotoxicity against human U-937 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
Cytotoxicity against human U-937 cells assessed as reduction in cell growth incubated for 48 hrs by CCK-8 assay
[PMID: 38181652]
体外実験

Fumitremorgin B (3 or 4 days) inhibits the proliferation of U937 and PC3 cells, with IC50 of 14.12 and 43.36 μM, respectively[2].
Fumitremorgin B exhibits antifungal activities against the phytopathogenic fungi B. cinerea, A. solani, A. alternata, C. gloeosporioides, F. solani, F. oxysporum f. sp. niveum, F. oxysporum f. sp. vasinfectum, and G. saubinettii, with MICs of 6.25-50 μg/mL[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fumitremorgin B 関連抗体
分子量

479.57

分子式

C27H33N3O5
CAS 番号
Appearance

Oil

Color

Off-white to light brown

SMILES

O=C([C@]1(O)[C@@H](O)C2=C([C@H](/C=C(C)\C)N13)N(C/C=C(C)\C)C4=C2C=CC(OC)=C4)N5[C@](CCC5)([H])C3=O
Structure Classification
Initial Source

fungus Aspergillus fumigatus
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Pure form -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
純度とドキュメンテーション

純度: ≥90.0%

COA (257 KB)

取扱説明書 (2659 KB)
参考文献
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Fumitremorgin B Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fumitremorgin B12626-17-4FungalEndogenous MetabolitetremorgenicmycotoxinantifungalInhibitorinhibitorinhibit

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製品名:
Fumitremorgin B
製品番号:
HY-117313
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