Garcinia cambogia extract

Name: Garcinia cambogia extract
Brand: MedChemExpress
SKU: HY-N14035
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Garcinia cambogia extract is an orally active anti-obesity agent. Garcinia cambogia extract upregulates the gene expression of aP2, SREBP1c, PPARγ2 and C/EBPα. Garcinia cambogia extract reduces the rate of body weight gain, visceral fat accumulation, lipid levels in blood and liver, as well as plasma insulin and leptin levels. Garcinia cambogia extract ameliorates high-fat diet-induced obesity.

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Garcinia cambogia extract Estructura química

No. CAS : 90045-23-1

Tamaño	Stock	Cantidad
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
1 g	En stock	Estimated Time of Arrival: December 31
5 g	En stock	Estimated Time of Arrival: December 31
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50 g	Obtener un presupuesto

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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Descripciòn

Garcinia cambogia extract is an orally active anti-obesity agent^[1]. Garcinia cambogia extract upregulates the gene expression of aP2, SREBP1c, PPARγ2 and C/EBPα. Garcinia cambogia extract reduces the rate of body weight gain, visceral fat accumulation, lipid levels in blood and liver, as well as plasma insulin and leptin levels^[1]^[2]. Garcinia cambogia extract ameliorates high-fat diet-induced obesity^[1]^[2].

IC₅₀ & Target^[1]

PPARγ2

aP2

In Vivo

Garcinia cambogia extract (10000 ppm; dietary incorporation; ad libitum daily; 12 weeks) reduces HFD-induced obesity in male C57BL/6J mice by decreasing body weight gain, visceral adiposity, and dyslipidemia, and normalizing adipogenesis-related gene expression in visceral fat tissue^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6J (7-week-old male, high-fat diet-induced obesity model)^[1]
Dosage:	10 g/kg diet (extract contained 60% hydroxycitric acid)
Administration:	dietary incorporation; ad libitum daily; 12 weeks
Result:	Reduced final body weight by 22% and 12-week body weight gain by 46% compared to HFD-fed controls. Reduced food intake and food efficiency ratio significantly compared to HFD-fed controls. Reduced total visceral fat depot weight by 39% compared to HFD-fed controls; epididymal, perirenal, retroperitoneal, and mesenteric fat pad weights were reduced by 37%, 48%, 36%, and 42% respectively. Reduced mean epididymal adipocyte surface area by 34% compared to HFD-fed controls. Reduced plasma total cholesterol by 24% and plasma triglycerides by 25% compared to HFD-fed controls. Reduced liver weight by 18%, hepatic triglyceride levels by 14%, and hepatic cholesterol levels by 15% compared to HFD-fed controls. Reduced plasma insulin levels by 43% and plasma leptin levels by 52% compared to HFD-fed controls. Increased aP2 mRNA by 120%, SREBP1c mRNA by 12%, C/EBPα mRNA by 174%, and PPARγ2 mRNA by 70% in epididymal fat tissue compared to HFD-fed controls. Decreased TNFα mRNA by 20% in epididymal fat tissue compared to HFD-fed controls.

No. CAS

90045-23-1

Appearance

Solid

Color

Off-white to light yellow

SMILES

[Garcinia cambogia extract]

Structure Classification

Others

Initial Source

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

H₂O : 20 mg/mL (Need ultrasonic)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

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Referencias

[1]. Kim KY, et al. Garcinia cambogia extract ameliorates visceral adiposity in C57BL/6J mice fed on a high-fat diet. Biosci Biotechnol Biochem. 2008 Jul;72(7):1772-80. [Content Brief]