GDP-D-mannose disodium

Name: GDP-D-mannose disodium
Brand: MedChemExpress
SKU: HY-N7389A
Rating: 4.5 (0 reviews)

Cat. No.: HY-N7389A Purity: 99.97%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

GDP-D-mannose disodium consists of GDP-α-D-mannose (HY-N7389B) and GDP-β-D-mannose. GDP-α-D-mannose serves as a donor substrate for mannosyltransferases and acts as a precursor of GDP-β-L-fucose. GDP-α-D-mannose exerts competitive inhibition on GTP (with a K_i value of 14.7 μM) and non-competitive inhibition on mannose-1-P (with a K_i value of 115 μM). GDP-D-mannose disodium is metabolized to GDP-L-fucose (HY-134433) via GMDS (Gmd) and TSTA3 (WcaG).

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GDP-D-mannose disodium 화학구조

CAS No. : 103301-73-1

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of GDP-D-mannose disodium:

GDP-α-D-mannose disodium In-stock

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Human Endogenous Metabolite Microbial Metabolite

Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

GDP-D-mannose disodium acts as the substrate for the GMDS/TSTA3-mediated metabolic pathway in engineered E. coli BL21 (DE3) cells to produce GDP-L-fucose^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

649.30

화학식

C₁₆H₂₃N₅Na₂O₁₆P₂

CAS No.

103301-73-1

Appearance

Solid

Color

White to off-white

SMILES

O=P(OP(OC1[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1)(O[Na])=O)(O[Na])OC[C@@H](O2)[C@@H](O)[C@@H](O)[C@@H]2N3C(N=C(N)NC4=O)=C4N=C3

Structure Classification

Others

Initial Source

Endogenous metabolite

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

H₂O : 100 mg/mL (154.01 mM; Need ultrasonic)

DMSO : 11.76 mg/mL (18.11 mM; ultrasonic and adjust pH to 3 with 1M HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5401 mL	7.7006 mL	15.4012 mL
5 mM	0.3080 mL	1.5401 mL	3.0802 mL
10 mM	0.1540 mL	0.7701 mL	1.5401 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 99.97%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (252 KB) HNMR (313 KB) RP-HPLC (274 KB) MS (254 KB)

Handling Instructions (2659 KB)

References

[1]. Elling L, et al. Expression, purification and characterization of recombinant phosphomannomutase and GDP-alpha-D-mannose pyrophosphorylase from Salmonella enterica, group B, for the synthesis of GDP-alpha-D-mannose from D-mannose. Glycobiology. 1996 Sep;6(6):591-7. [Content Brief]

[2]. REHMAN B H. Mannose utilization under hypoxic conditions in cancer cells[D]. The University of Huddersfield, 2023.

[3]. Cui C, et al. Odoribacter splanchnicus rescues aging-related intestinal P-glycoprotein damage via GDP-L-fucose secretion. Nat Commun. 2025;16(1):10665. Published 2025 Nov 27.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	1.5401 mL	7.7006 mL	15.4012 mL	38.5030 mL
	5 mM	0.3080 mL	1.5401 mL	3.0802 mL	7.7006 mL
	10 mM	0.1540 mL	0.7701 mL	1.5401 mL	3.8503 mL
	15 mM	0.1027 mL	0.5134 mL	1.0267 mL	2.5669 mL
H₂O	20 mM	0.0770 mL	0.3850 mL	0.7701 mL	1.9252 mL
	25 mM	0.0616 mL	0.3080 mL	0.6160 mL	1.5401 mL
	30 mM	0.0513 mL	0.2567 mL	0.5134 mL	1.2834 mL
	40 mM	0.0385 mL	0.1925 mL	0.3850 mL	0.9626 mL
	50 mM	0.0308 mL	0.1540 mL	0.3080 mL	0.7701 mL
	60 mM	0.0257 mL	0.1283 mL	0.2567 mL	0.6417 mL
	80 mM	0.0193 mL	0.0963 mL	0.1925 mL	0.4813 mL
	100 mM	0.0154 mL	0.0770 mL	0.1540 mL	0.3850 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.