2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. Giripladib

Giripladib  (Synonyms: PLA-695)

製品番号: HY-14952 純度: 99.68%
COA 取扱説明書 Technical Support

Giripladib (PLA-695) is a indole-based inhibitor of cytosolic phospholipase A2 (cPLA2). Giripladib can be used for osteoarthritis and breast cancer research.

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Giripladib

Giripladib 構造式

CAS 番号 : 865200-20-0

容量 価格（税別） 在庫状況 数量
1 mg $235 在庫あり
5 mg $588 在庫あり
10 mg $880 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

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Giripladib 関連抗体

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Phospholipase アイソフォーム固有の製品をすべて表示:

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Phospholipase A PLD Phospholipase C

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製品説明

Giripladib (PLA-695) is a indole-based inhibitor of cytosolic phospholipase A2 (cPLA2). Giripladib can be used for osteoarthritis and breast cancer research[1][2].

IC50 & Target

cPLA2α

 

臨床実験
分子量

745.25

分子式

C41H36ClF3N2O4S
CAS 番号
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C1=CC=C(CCCC2=C(CCNS(=O)(CC3=C(C(F)(F)F)C=CC=C3)=O)N(C(C4=CC=CC=C4)C5=CC=CC=C5)C6=C2C=C(C=C6)Cl)C=C1)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 125 mg/mL (167.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3418 mL 6.7092 mL 13.4183 mL
5 mM 0.2684 mL 1.3418 mL 2.6837 mL
10 mM 0.1342 mL 0.6709 mL 1.3418 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3418 mL 6.7092 mL 13.4183 mL 33.5458 mL
5 mM 0.2684 mL 1.3418 mL 2.6837 mL 6.7092 mL
10 mM 0.1342 mL 0.6709 mL 1.3418 mL 3.3546 mL
15 mM 0.0895 mL 0.4473 mL 0.8946 mL 2.2364 mL
20 mM 0.0671 mL 0.3355 mL 0.6709 mL 1.6773 mL
25 mM 0.0537 mL 0.2684 mL 0.5367 mL 1.3418 mL
30 mM 0.0447 mL 0.2236 mL 0.4473 mL 1.1182 mL
40 mM 0.0335 mL 0.1677 mL 0.3355 mL 0.8386 mL
50 mM 0.0268 mL 0.1342 mL 0.2684 mL 0.6709 mL
60 mM 0.0224 mL 0.1118 mL 0.2236 mL 0.5591 mL
80 mM 0.0168 mL 0.0839 mL 0.1677 mL 0.4193 mL
100 mM 0.0134 mL 0.0671 mL 0.1342 mL 0.3355 mL
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Giripladib Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Giripladib865200-20-0PLA-695PLA695PLA 695PhospholipaseOsteoarthritisBCSCstumorigenesisbreast cancer stem cellscytosolic phospholipase A2Inhibitorinhibitorinhibit

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製品番号:
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