2. Metabolic Enzyme/Protease Apoptosis
  3. Hexokinase Apoptosis
  4. Benitrobenrazide

Benitrobenrazide  (Synonyms: BNBZ; Hexokinase 2 inhibitor 1)

Cat. No.: HY-134929 Purity: 99.91%
COA
SDS
Handling Instructions Technical Support

Benitrobenrazide (BNBZ) is the orally active inhibitor for hexokinase 2 with an IC50 of 0.53 µM. Benitrobenrazide causes DNA damage, and exhibits antitumor effect.

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Benitrobenrazide

Benitrobenrazide 화학구조

CAS No. : 2454676-05-0

사이즈 가격 재고 수량
무료 샘플 (0.1 - 0.2 mg)   지금 신청하기  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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고객리뷰

Based on 2 publication(s) in Google Scholar

Benitrobenrazide Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Benitrobenrazide (BNBZ) is the orally active inhibitor for hexokinase 2 with an IC50 of 0.53 µM. Benitrobenrazide causes DNA damage, and exhibits antitumor effect[1][2].

In Vitro

Benitrobenrazide exhibits cytotoxicity to HepG2, HUH7, SW1990 and SW480 cells with IC50s of 15.0 µM, 57.1 µM, 24 µM and 7.13 µM, respectively[1][2].
Benitrobenrazide (0-80 µM, 72 h) arrests the cell cycle at G1 phase in Huh7 cell, promotes the generation of ROS, and induces apoptosis in SW1990 and MIApaca-2[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Benitrobenrazide Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HepG2 and HUH7
Concentration: 0-500 µM
Incubation Time: 72 h
Result: Inhibited the proliferation of HepG2 and HUH7.

Apoptosis Analysis[2]

Cell Line: SW1990 and MIApaca-2
Concentration: 0-80 µM
Incubation Time: 48 h
Result: Induced apoptosis.
In Vivo

Benitrobenrazide (75-150 mg/kg, po, once daily for 20 days) exhibits antitumor effect in mouse SW1990/SW480 xenograft models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse SW1990/SW480 xenograft models[2]
Dosage: 75-150 mg/kg
Administration: po, once daily for 20 days
Result: Inhibited tumor growth.
분자량

317.25

화학식

C14H11N3O6
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C(N/N=C/C1=CC=C(O)C(O)=C1O)C2=CC=C([N+]([O-])=O)C=C2
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 100 mg/mL (315.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1521 mL 15.7604 mL 31.5209 mL
5 mM 0.6304 mL 3.1521 mL 6.3042 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 99.91%

SDS (251 KB)

COA (246 KB) HNMR (272 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1521 mL 15.7604 mL 31.5209 mL 78.8022 mL
5 mM 0.6304 mL 3.1521 mL 6.3042 mL 15.7604 mL
10 mM 0.3152 mL 1.5760 mL 3.1521 mL 7.8802 mL
15 mM 0.2101 mL 1.0507 mL 2.1014 mL 5.2535 mL
20 mM 0.1576 mL 0.7880 mL 1.5760 mL 3.9401 mL
25 mM 0.1261 mL 0.6304 mL 1.2608 mL 3.1521 mL
30 mM 0.1051 mL 0.5253 mL 1.0507 mL 2.6267 mL
40 mM 0.0788 mL 0.3940 mL 0.7880 mL 1.9701 mL
50 mM 0.0630 mL 0.3152 mL 0.6304 mL 1.5760 mL
60 mM 0.0525 mL 0.2627 mL 0.5253 mL 1.3134 mL
80 mM 0.0394 mL 0.1970 mL 0.3940 mL 0.9850 mL
100 mM 0.0315 mL 0.1576 mL 0.3152 mL 0.7880 mL
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Benitrobenrazide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benitrobenrazide2454676-05-0BNBZ Hexokinase 2 inhibitor 1HexokinaseApoptosisorally activeHepG2HUH7SW1990SW480Inhibitorinhibitorinhibit

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상품명:
Benitrobenrazide
Cat. No.:
HY-134929
수량:
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SAFETY DATA SHEET (SDS)

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