2454676-05-0
2454676-05-0
Chemical Structure
Benitrobenrazide
Synonym(s): BNBZ; Hexokinase 2 inhibitor 1
- CAS No.: 2454676-05-0
- Formula:C14H11N3O6
- Molecular Weight:317.25
IUPAC Name: (E)-4-nitro-N'-(2,3,4-trihydroxybenzylidene)benzohydrazide
InChIKey: OQNGYRBQYWPKIC-VIZOYTHASA-N
SMILES: O=C(N/N=C/C1=CC=C(O)C(O)=C1O)C2=CC=C([N+]([O-])=O)C=C2
Biological Activity: Benitrobenrazide (BNBZ) is the orally active inhibitor for hexokinase 2 with an IC50 of 0.53 µM. Benitrobenrazide causes DNA damage, and exhibits antitumor effect[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Benitrobenrazide | 99.50% | Benitrobenrazide (BNBZ) is the orally active inhibitor for hexokinase 2 with an IC50 of 0.53 µM. Benitrobenrazide causes DNA damage, and exhibits antitumor effect. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Juszczak K, et al. Hexokinase 2 Inhibition and Biological Effects of BNBZ and Its Derivatives: The Influence of the Number and Arrangement of Hydroxyl Groups. Int J Mol Sci. 2022 Feb 27;23(5):2616. [Content Brief]
- [2]. Zheng M, et al., Novel selective hexokinase 2 inhibitor Benitrobenrazide blocks cancer cells growth by targeting glycolysis. Pharmacol Res. 2021 Feb;164:105367. [Content Brief]
Keywords
