Benitrobenrazide
Based on 2 publication(s) in Google Scholar
Benitrobenrazide (BNBZ) is the orally active inhibitor for hexokinase 2 with an IC50 of 0.53 µM. Benitrobenrazide causes DNA damage, and exhibits antitumor effect.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.50%
- CAS. Nr.: 2454676-05-0
- Formel: C14H11N3O6
- Molecular Weight:317.25
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Apoptosis Compound Library
HY-L003
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Kinase Inhibitor Library
HY-L009
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cancer Compound Library
HY-L025
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Glycolysis Compound Library
HY-L058
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Orally Active Compound Library
HY-L061
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Anti-Cancer Metabolism Compound Library
HY-L083
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Glucose Metabolism Compound Library
HY-L092
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Metabolic Enzyme Compound Library
HY-L146
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Cell Death Library
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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HY-L204
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) Benitrobenrazide
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Biologische Aktivität
Benitrobenrazide exhibits cytotoxicity to HepG2, HUH7, SW1990 and SW480 cells with IC50s of 15.0 µM, 57.1 µM, 24 µM and 7.13 µM, respectively[1][2].
Benitrobenrazide (0-80 µM, 72 h) arrests the cell cycle at G1 phase in Huh7 cell, promotes the generation of ROS, and induces apoptosis in SW1990 and MIApaca-2[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse SW1990/SW480 xenograft models[2]
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Dosage:75-150 mg/kg
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Administration:po, once daily for 20 days
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Result:Inhibited tumor growth.
Chemical Information
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CAS. Nr. 2454676-05-0
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Appearance Solid
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Molecular Weight 317.25
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Formel C14H11N3O6
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Color Yellow to orange
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SMILES
O=C(N/N=C/C1=CC=C(O)C(O)=C1O)C2=CC=C([N+]([O-])=O)C=C2
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Synonyms
BNBZ; Hexokinase 2 inhibitor 1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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FASEB J
Limonin Is a Novel Hexokinase 2 Inhibitor That Suppresses Hepatic Stellate Cell Activation and Histone Lactylation. [Abstract]2026 Feb 15;40(3):e71547. PMID: 41649270 -
NPJ Gut Liver
2025;2(1):32. PMID: 41357846
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (315.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Juszczak K, et al. Hexokinase 2 Inhibition and Biological Effects of BNBZ and Its Derivatives: The Influence of the Number and Arrangement of Hydroxyl Groups. Int J Mol Sci. 2022 Feb 27;23(5):2616. [Content Brief]
[2]. Zheng M, et al., Novel selective hexokinase 2 inhibitor Benitrobenrazide blocks cancer cells growth by targeting glycolysis. Pharmacol Res. 2021 Feb;164:105367. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1521 mL | 15.7604 mL | 31.5209 mL | 78.8022 mL |
| 5 mM | 0.6304 mL | 3.1521 mL | 6.3042 mL | 15.7604 mL | |
| 10 mM | 0.3152 mL | 1.5760 mL | 3.1521 mL | 7.8802 mL | |
| 15 mM | 0.2101 mL | 1.0507 mL | 2.1014 mL | 5.2535 mL | |
| 20 mM | 0.1576 mL | 0.7880 mL | 1.5760 mL | 3.9401 mL | |
| 25 mM | 0.1261 mL | 0.6304 mL | 1.2608 mL | 3.1521 mL | |
| 30 mM | 0.1051 mL | 0.5253 mL | 1.0507 mL | 2.6267 mL | |
| 40 mM | 0.0788 mL | 0.3940 mL | 0.7880 mL | 1.9701 mL | |
| 50 mM | 0.0630 mL | 0.3152 mL | 0.6304 mL | 1.5760 mL | |
| 60 mM | 0.0525 mL | 0.2627 mL | 0.5253 mL | 1.3134 mL | |
| 80 mM | 0.0394 mL | 0.1970 mL | 0.3940 mL | 0.9850 mL | |
| 100 mM | 0.0315 mL | 0.1576 mL | 0.3152 mL | 0.7880 mL |
Benitrobenrazide Related Classifications
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