2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Homatropine

Homatropine is an orally active muscarinic acetylcholine receptor antagonist and can be used as an anticholinergic agent.

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Homatropine

Homatropine 화학구조

CAS No. : 87-00-3

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Other Forms of Homatropine:

Homatropine Related Antibodies

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제품 설명

Homatropine is an orally active muscarinic acetylcholine receptor antagonist and can be used as an anticholinergic agent[1].

In Vitro

Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs, and produces a dose ratio of only 95.0 when combined with Hexamethonium Bromide.html" class="link-product" target="_blank">Hexamethonium Bromide (HY-B0569) in atrium from guinea-pigs[1].
Homatropine has affinities for muscarinic receptors in stomach (pA2 = 7.13) and for those in atria mediating force (pA2 = 7.21) and rate (pA2 = 7.07) responses[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Homatropine Related Antibodies
In Vivo

Homatropine methylbromide (9 mm x 5 mm conical suppository) causes prompt blockade of the effects of vagal stimulation on pulse rate and of intravenous acetylcholine on blood pressure in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male albino rats[3]
Dosage: 9 mm x 5 mm conical suppository
Administration: By suppository
Result: Blocked cardiovascular responses to vagal stimulation and acetylcholine; 10-20 min after insertion of the suppository the effects of vagal stimulation over a range of 2-16 Hz, 5 V, on pulse rate was virtually abolished and remained unchanged at 45-60 min.
Clinical Trial
분자량

275.34

화학식

C16H21NO3
CAS No.
SMILES

O=C(C(C1=CC=CC=C1)O)O[C@H]2C[C@@H](CC3)N(C)[C@@H]3C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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Homatropine Related Classifications

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Homatropine87-00-3mAChRMuscarinic acetylcholine receptoranticholinergicsuppositoryInhibitorinhibitorinhibit

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상품명:
Homatropine
Cat. No.:
HY-B0547
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