1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR

Homatropine methylbromide (Synonyms: Homatropine methobromide)

Cat. No.: HY-B1388 Purity: >98.0%
Handling Instructions

Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.

For research use only. We do not sell to patients.

Homatropine methylbromide Chemical Structure

Homatropine methylbromide Chemical Structure

CAS No. : 80-49-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
200 mg USD 120 In-stock
Estimated Time of Arrival: December 31
500 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Customer Review

Other Forms of Homatropine methylbromide:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively. target: mAChR IC 50: WKY-E(162.5 nM), SHR-E(170.4nM ) In vitro: Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs. In vivo: : Pre-treatment with homatropine (20 mg/kg) was comparable with atropine (10 mg/kg) in preventing lethality in this rat model of acute OC poisoning. All rats pre-treated with normal saline, atropine 5 mg/kg, and homatropine 10 mg/kg died. Survival in the homatropine (20 mg/kg) and atropine (10 mg/kg) groups was 30% and 40% respectively.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (83.72 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7007 mL 13.5033 mL 27.0066 mL
5 mM 0.5401 mL 2.7007 mL 5.4013 mL
10 mM 0.2701 mL 1.3503 mL 2.7007 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

370.28

Formula

C₁₇H₂₄BrNO₃

CAS No.

80-49-9

SMILES

C[N+]1([[email protected]@H]2C[[email protected]@H](OC(C(O)C3=CC=CC=C3)=O)C[[email protected]]1CC2)C.[Br-]

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Homatropine methylbromide
Cat. No.:
HY-B1388
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Homatropine methylbromide

Cat. No.: HY-B1388