1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR

Homatropine methylbromide (Synonyms: Homatropine methobromide)

Cat. No.: HY-B1388
Handling Instructions

Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.

For research use only. We do not sell to patients.
Homatropine methylbromide Chemical Structure

Homatropine methylbromide Chemical Structure

CAS No. : 80-49-9

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10 mM * 1 mL in DMSO $55 In-stock
50 mg $50 In-stock
100 mg $60 In-stock
200 mg $100 In-stock
500 mg $150 In-stock
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Other Forms of Homatropine methylbromide:

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Description

Homatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively. target: mAChR IC 50: WKY-E(162.5 nM), SHR-E(170.4nM ) In vitro: Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs. In vivo: : Pre-treatment with homatropine (20 mg/kg) was comparable with atropine (10 mg/kg) in preventing lethality in this rat model of acute OC poisoning. All rats pre-treated with normal saline, atropine 5 mg/kg, and homatropine 10 mg/kg died. Survival in the homatropine (20 mg/kg) and atropine (10 mg/kg) groups was 30% and 40% respectively.

References
Molecular Weight

370.28

Formula

C₁₇H₂₄BrNO₃

CAS No.

80-49-9

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 31 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Homatropine methylbromide
Cat. No.:
HY-B1388
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