1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Apoptosis
  2. nAChR
    Apoptosis
  3. Hexamethonium Bromide

Hexamethonium Bromide 

Cat. No.: HY-B0569 Purity: >98.0%
Handling Instructions

Hexamethonium Bromide is a non-depolarising ganglionic blocker, a nicotinic nACh (NN) receptor antagonist.

For research use only. We do not sell to patients.

Hexamethonium Bromide Chemical Structure

Hexamethonium Bromide Chemical Structure

CAS No. : 55-97-0

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Hexamethonium Bromide is a non-depolarising ganglionic blocker, a nicotinic nACh (NN) receptor antagonist. Target: nAChR Hexamethonium Bromide is a non-depolarising ganglionic blocker, a nicotinic nACh receptor antagonist that acts in autonomic ganglia by binding mostly in or on the NN receptor, and not the acetylcholine binding site itself. It does not have any effect on the muscarinic acetylcholine receptors (mAChR) located on target organs of the parasympathetic nervous system but acts as antagonist at the nicotinic acetylcholine receptors located in sympathetic and parasympathetic ganglia (NN). Hexamethonium Bromide is a nicotinic acetyl choline receptor antagonist. Induces apoptosis and inhibits the stimulatory effect of nicotine on endothelial cell DNA synthesis and proliferation. Hexamethonium bromide hydrate is an inhibitor of AChR α3 [1-3].

Molecular Weight

362.19

Formula

C₁₂H₃₀Br₂N₂

CAS No.

55-97-0

SMILES

C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (276.10 mM)

DMSO : 16.67 mg/mL (46.03 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7610 mL 13.8049 mL 27.6098 mL
5 mM 0.5522 mL 2.7610 mL 5.5220 mL
10 mM 0.2761 mL 1.3805 mL 2.7610 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (4.61 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.67 mg/mL (4.61 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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Keywords:

HexamethoniumnAChRApoptosisNicotinic acetylcholine receptorsInhibitorinhibitorinhibit

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Hexamethonium Bromide
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