55-97-0
55-97-0
Chemical Structure
Hexamethonium Bromide
- CAS No.: 55-97-0
- Formula:C12H30Br2N2
- Molecular Weight:362.19
IUPAC Name: N1,N1,N1,N6,N6,N6-hexamethylhexane-1,6-diaminium bromide
InChIKey: FAPSXSAPXXJTOU-UHFFFAOYSA-L
SMILES: C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]
Biological Activity: Hexamethonium Bromide is a non-selective ganglionic nicotinic-receptor antagonist (nAChR) antagonist, with mixed competitive and noncompetitive activity. Hexamethonium Bromide has anti-hypertensive activity. Hexamethonium Bromide attenuates sympathetic activity and blood pressure in spontaneously hypertensive animal models[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Hexamethonium Bromide | 99.75% | Hexamethonium Bromide is a non-selective ganglionic nicotinic-receptor antagonist (nAChR) antagonist, with mixed competitive and noncompetitive activity. Hexamethonium Bromide has anti-hypertensive activity. Hexamethonium Bromide attenuates sympathetic activity and blood pressure in spontaneously hypertensive animal models. | ||||||||||||||||||||
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Decamethonium chloride | Decamethonium chloride is a depolarizing neuromuscular blocking agent that can be used to study the mechanism of action of muscle relaxants. | |||||||||||||||||||||
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Decamethonium Bromide(Reagent for Ion-Pair Chromatography,99%) | 99.64% | Decamethonium bromide(Reagent for Ion-Pair Chromatography,99%) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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Cetrimonium bromide | 98.0% | Cetrimonium bromide (CTAB), a quaternary ammonium, is an orally active cationic surfaetant. Cetrimonium bromide has toxicity and anticancer effect. Cetrimonium bromide inhibits cell migration and invasion through modulating the canonical and non-canonical TGF-β signaling pathways. Cetrimonium bromide can be used for DNA extraction. | ||||||||||||||||||||
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Hexamethonium chloride | 99.49% | Hexamethonium Chloride Dihydrate is a synthetic organic compound commonly used as a ganglion blocking agent, which means it blocks the transmission of nerve impulses between ganglion cells in the autonomic nervous system. Hexamethonium Chloride Dihydrate is used in various medical applications such as lowering blood pressure or inhibiting certain types of neuropathic pain. It works by inhibiting the release of acetylcholine, a neurotransmitter that plays a key role in regulating many bodily functions. | ||||||||||||||||||||
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Dodecyltrimethylammonium bromide | 99.97% | Dodecyltrimethylammonium bromide (DTAB) is a surfactant. Dodecyltrimethylammonium bromide interacts with DNA and changes the mechanical properties of DNA on binding and the specific binding parameters of the interaction. | ||||||||||||||||||||
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Tetradecyltrimethylammonium bromide | 98.0% | Tetradecyltrimethylammonium bromide (TTAB; TTABr; MiTMAB), an organic building block, is a cationic surfactant with asymmetrical structure. | ||||||||||||||||||||
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Tetradecyltrimethylammonium chloride | 98.0% | Tetradecyltrimethylammonium chloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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DTAC,for IPC,≥99% | 99.0% | DTAC (Dodecyltrimethylammonium chloride), for IPC, ≥99% is a quaternary ammonium cationic surfactant. DTAC, for IPC, ≥99% can form micelles in aqueous media, which interact with and encapsulate Diclofenac sodium (HY-15037) molecules; the micellization process is entropy-driven at lower temperatures and enthalpy-driven at higher temperatures. | ||||||||||||||||||||
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Hexyldimethyloctylammonium bromide | Hexyldimethyloctylammonium Bromide is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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Decamethonium iodide | Decamethonium (iodide) is an organic compound containing ammonium and iodide ions. It is commonly used as a neuromuscular blocking agent in anesthesia to induce muscle relaxation during surgery. Decamethonium Iodide acts by binding to nicotinic acetylcholine receptors (nAChRs) in the neuromuscular junction, causing depolarization block and subsequent skeletal muscle paralysis. In addition, it can also serve as a reference standard for pharmacological studies of nAChRs. | |||||||||||||||||||||
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References
- [1]. Damian J. Williams, et al. Mechanisms involved in nicotinic acetylcholine receptor-induced neurotransmitter release from sympathetic nerve terminals in the mouse vas deferens. PLoS One. 2011; 6(12): e29209. [Content Brief]
- [2]. Roger L. Papke, et al. Activation and Inhibition of Mouse Muscle and Neuronal Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes. J Pharmacol Exp Ther. 2010 May; 333(2): 501–518. [Content Brief]
- [3]. Brian T Hawkins, et al. Modulation of cerebral microvascular permeability by endothelial nicotinic acetylcholine receptors. Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H212-9. [Content Brief]
- [4]. Peng Li, et al. Hexamethonium attenuates sympathetic activity and blood pressure in spontaneously hypertensive rats. Mol Med Rep. 2015 Nov;12(5):7116-22. [Content Brief]
