55-97-0
Chemical Structure
Hexamethonium Bromide
- CAS No.: 55-97-0
- Formula:C12H30Br2N2
- Molecular Weight:362.19
IUPAC Name: N1,N1,N1,N6,N6,N6-hexamethylhexane-1,6-diaminium bromide
InChIKey: FAPSXSAPXXJTOU-UHFFFAOYSA-L
SMILES: C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-]
Biological Activity: Hexamethonium Bromide is a non-selective ganglionic nicotinic-receptor antagonist (nAChR) antagonist, with mixed competitive and noncompetitive activity. Hexamethonium Bromide has anti-hypertensive activity. Hexamethonium Bromide attenuates sympathetic activity and blood pressure in spontaneously hypertensive animal models[1][2][3][4].
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Hexamethonium Bromide | 99.75% | Hexamethonium Bromide is a non-selective ganglionic nicotinic-receptor antagonist (nAChR) antagonist, with mixed competitive and noncompetitive activity. Hexamethonium Bromide has anti-hypertensive activity. Hexamethonium Bromide attenuates sympathetic activity and blood pressure in spontaneously hypertensive animal models. | ||||||||||||||||||||
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- [1]. Damian J. Williams, et al. Mechanisms involved in nicotinic acetylcholine receptor-induced neurotransmitter release from sympathetic nerve terminals in the mouse vas deferens. PLoS One. 2011; 6(12): e29209. [Content Brief]
- [2]. Roger L. Papke, et al. Activation and Inhibition of Mouse Muscle and Neuronal Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes. J Pharmacol Exp Ther. 2010 May; 333(2): 501–518. [Content Brief]
- [3]. Brian T Hawkins, et al. Modulation of cerebral microvascular permeability by endothelial nicotinic acetylcholine receptors. Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H212-9. [Content Brief]
- [4]. Peng Li, et al. Hexamethonium attenuates sympathetic activity and blood pressure in spontaneously hypertensive rats. Mol Med Rep. 2015 Nov;12(5):7116-22. [Content Brief]
Keywords
