Infigratinib-Boc

Art. -Nr.: HY-160124 Reinheit: 98.29%: Data Sheet
COA

SDS
Handling Instructions
FAQs
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Infigratinib-Boc is a derivative of Infigratinib containing a Boc (t-Butyloxy carbonyl) group. Infigratinib is an ATP-competitive pan-FGFR inhibitor.

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Infigratinib-Boc Chemische Struktur

CAS. Nr. : 2504949-83-9

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
200 mg	Angebot einholen
500 mg	Angebot einholen

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This product is a controlled substance and not for sale in your territory.

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
Reinheit & Dokumentation
Verweise
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Beschreibung

Infigratinib-Boc is a derivative of Infigratinib containing a Boc (t-Butyloxy carbonyl) group. Infigratinib is an ATP-competitive pan-FGFR inhibitor^[1].

Molekulargewicht

632.54

Formel

C₂₉H₃₅Cl₂N₇O₅

CAS. Nr.

2504949-83-9

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=C(Cl)C(OC)=CC(OC)=C1Cl)N(C)C2=CC(NC(C=C3)=CC=C3N4CCN(C(OC(C)(C)C)=O)CC4)=NC=N2

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (158.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5809 mL	7.9046 mL	15.8093 mL
5 mM	0.3162 mL	1.5809 mL	3.1619 mL
10 mM	0.1581 mL	0.7905 mL	1.5809 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 98.29%

Select Batch:

Data Sheet (266 KB) SDS (251 KB)

COA (246 KB) HNMR (322 KB) LCMS (110 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Guangyan Du, et al. Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2. Angew Chem Int Ed Engl. 2021 Jul 12;60(29):15905-15911. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5809 mL	7.9046 mL	15.8093 mL	39.5232 mL
	5 mM	0.3162 mL	1.5809 mL	3.1619 mL	7.9046 mL
	10 mM	0.1581 mL	0.7905 mL	1.5809 mL	3.9523 mL
	15 mM	0.1054 mL	0.5270 mL	1.0540 mL	2.6349 mL
	20 mM	0.0790 mL	0.3952 mL	0.7905 mL	1.9762 mL
	25 mM	0.0632 mL	0.3162 mL	0.6324 mL	1.5809 mL
	30 mM	0.0527 mL	0.2635 mL	0.5270 mL	1.3174 mL
	40 mM	0.0395 mL	0.1976 mL	0.3952 mL	0.9881 mL
	50 mM	0.0316 mL	0.1581 mL	0.3162 mL	0.7905 mL
	60 mM	0.0263 mL	0.1317 mL	0.2635 mL	0.6587 mL
	80 mM	0.0198 mL	0.0988 mL	0.1976 mL	0.4940 mL
	100 mM	0.0158 mL	0.0790 mL	0.1581 mL	0.3952 mL