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IP7e 

Cat. No.: HY-110274
Handling Instructions

IP7e is a potent, brain-penetrant and orally active Nurr1 activator with an EC50 value of 3.9 nM.

For research use only. We do not sell to patients.

IP7e Chemical Structure

IP7e Chemical Structure

CAS No. : 500164-74-9

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Description

IP7e is a potent, brain-penetrant and orally active Nurr1 activator with an EC50 value of 3.9 nM[1].

IC50 & Target

EC50: 3.9 nM (Nurr1)[1]

In Vivo

IP7e (Isoxazolo-pyridinone 7e; 10 mg/kg; oral gavage; twice a day) preventive treatment reduces the incidence and the severity of a MS murine model, i.e. experimental autoimmune encephalomyelitis (EAE). IP7e attenuates inflammation and neurodegeneration in spinal cords of EAE mice by an NF-kB pathway-dependent process[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6J mice (6-8 week-old) with experimental autoimmune encephalomyelitis (EAE)[2].
Dosage: 10 mg/kg
Administration: Oral gavage; twice a day; preventive administration (before the disease onset) from 7 to 23 d.p.i. and therapeutic (after the disease onset) from 21 to 36 d.p.i.
Result: Preventive administration delayed the onset and reduces the incidence and severity of EAE, and decreased neuroinflammatory and histopathological alterations in the spinal cord of treated EAE mice. On the contrary, the course of EAE was not influenced by the therapeutic administration.
Molecular Weight

390.43

Formula

C₂₃H₂₂N₂O₄

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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IP7e
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HY-110274
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