2. Epigenetics Vitamin D Related/Nuclear Receptor
  3. Histone Acetyltransferase Estrogen Receptor/ERR
  4. KAT6-IN-4

KAT6-IN-4 (Compound Example 2) is a selective lysine acetyltransferase 6 (KAT6) inhibitor. KAT6-IN-4 suppresses transcription of oncogenes like ERα. KAT6-IN-4 demonstrates potent antitumor efficacy in ER+/HER2- breast cancer xenografts. KAT6-IN-4 is promising for research of KAT6-driven malignancies (e.g., breast cancer, NSCLC).

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KAT6-IN-4

KAT6-IN-4 Chemical Structure

CAS No. : 2901797-38-2

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KAT6-IN-4 Related Antibodies

Top Publications Citing Use of Products

Voir tous les produits spécifiques à Isoform Histone Acetyltransferase:

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CBP/p300 GCN5/PCAF TIP60 MOZ/MORF HBO1

Voir tous les produits spécifiques à Isoform Estrogen Receptor/ERR:

Voir toutes les isoformes
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

KAT6-IN-4 (Compound Example 2) is a selective lysine acetyltransferase 6 (KAT6) inhibitor. KAT6-IN-4 suppresses transcription of oncogenes like ERα. KAT6-IN-4 demonstrates potent antitumor efficacy in ER+/HER2- breast cancer xenografts. KAT6-IN-4 is promising for research of KAT6-driven malignancies (e.g., breast cancer, NSCLC)[1].

IC50 & Target

ERα

 

Masse moléculaire

470.50

Formule

C22H22N4O6S
CAS No.
SMILES

O=S(NC1=NOC2=CC(CN3N=CC=C3)=C4C(OCCC4)=C21)(C5=C(OC)C=CC=C5OC)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

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Pureté et documentation
Références
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KAT6-IN-4 Related Classifications

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Keywords:

KAT6-IN-42901797-38-2Histone AcetyltransferaseEstrogen Receptor/ERRHATsHATKAT6ERαbreast cancerInhibitorinhibitorinhibit

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