2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin Kinesin
  4. KIF18A-IN-2

KIF18A-IN-2 is a potent KIF18A inhibitor (IC50=28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer.

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KIF18A-IN-2

KIF18A-IN-2 화학구조

CAS No. : 2600559-20-2

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
1 mg 해외재고보유
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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KIF18A-IN-2 Related Antibodies

Top Publications Citing Use of Products

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Kinesin-5/Eg5/KSP Kinesin-6 Kinesin-7/CENP-E Kinesin-12 Kinesin-14 Kinesin-13

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

KIF18A-IN-2 is a potent KIF18A inhibitor (IC50=28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer[1].

IC50 & Target

IC50: 28 nM (KIF18A)[1]
Cellular Effect
Cell Line Type Value Description References
OVCAR-3 EC50
0.016 μM
Compound: 23
Antiproliferative activity against human OVCAR-3 cells by nuclear count assay
Antiproliferative activity against human OVCAR-3 cells by nuclear count assay
[PMID: 35286090]
OVCAR-3 EC50
0.016 μM
Compound: 23
Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay
Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay
[PMID: 35286090]
In Vivo

KIF18A-IN-2 (compound 23) (100 mg/kg; i.p., single) exhibits a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours[1]. Pharmacokinetic Parameters of KIF18A-IN-2 in female CD-1 mice[1].

IP (100 mg/kg)
Cmax (μM) 12.6
AUC0-24 (μM·h) 147
C24h (μM) 2.9
PPB (fu) 0.007

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nude mice (4-7 weeks; injected with human OVCAR-3 HGSOC cells)[1]
Dosage: 100 mg/kg
Administration: i.p., single
Result: Showed a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours.
분자량

534.69

화학식

C25H34N4O5S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(NS(C)(=O)=O)C=C1N2CCC3(CC3)CC2)NC4=CC=CC(S(NC(C)(C)C)(=O)=O)=C4
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 50 mg/mL (93.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8702 mL 9.3512 mL 18.7024 mL
5 mM 0.3740 mL 1.8702 mL 3.7405 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8702 mL 9.3512 mL 18.7024 mL 46.7561 mL
5 mM 0.3740 mL 1.8702 mL 3.7405 mL 9.3512 mL
10 mM 0.1870 mL 0.9351 mL 1.8702 mL 4.6756 mL
15 mM 0.1247 mL 0.6234 mL 1.2468 mL 3.1171 mL
20 mM 0.0935 mL 0.4676 mL 0.9351 mL 2.3378 mL
25 mM 0.0748 mL 0.3740 mL 0.7481 mL 1.8702 mL
30 mM 0.0623 mL 0.3117 mL 0.6234 mL 1.5585 mL
40 mM 0.0468 mL 0.2338 mL 0.4676 mL 1.1689 mL
50 mM 0.0374 mL 0.1870 mL 0.3740 mL 0.9351 mL
60 mM 0.0312 mL 0.1559 mL 0.3117 mL 0.7793 mL
80 mM 0.0234 mL 0.1169 mL 0.2338 mL 0.5845 mL
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KIF18A-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KIF18A-IN-22600559-20-2Microtubule/TubulinKinesinKIF18AMicrotubuleMitoticTubulinOVCAR-3CancerInhibitorinhibitorinhibit

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상품명:
KIF18A-IN-2
Cat. No.:
HY-145802
수량:
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