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    Apoptosis
  2. Bacterial
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    Apoptosis
  3. Lactoferrin (17-41) (acetate)

Lactoferrin (17-41) (acetate) (Synonyms: Lactoferricin B acetate; Lfcin B acetate)

Cat. No.: HY-P1791B Purity: 99.08%
Handling Instructions

Lactoferrin 17-41 (Lactoferricin B) acetate, a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 acetate has antitumor activities.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Lactoferrin (17-41) (acetate) Chemical Structure

Lactoferrin (17-41) (acetate) Chemical Structure

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5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Lactoferrin 17-41 (Lactoferricin B) acetate, a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 acetate has antitumor activities[1][2].

In Vitro

Lactoferrin 17-41 (Lactoferricin B) acetate has an MIC of 30 μg/ml against E. coli ATCC 25922[1].
Lactoferrin 17-41 acetate significantly stimulates apoptosis of HT-29 cells and displays cytotoxic activity on HT-29 cells[2].
Lactoferrin 17-41 acetate variously regulats transcription of genes involved in the p53 signaling pathway, such as PMAIP-1, TP5313, and SFN[2].
Lactoferrin 17-41 acetate can bind LPS from Gram-negative bacteria and that it can inhibit LPS induced cytokine response in human monocytic cells[1][3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HT-29 cells
Concentration: 50, 100, 200, 400, 800 or 1000 µg/mL
Incubation Time: 4, 12, 24 or 48 hours
Result: More effective at inducing apoptosis at 400 µg/mL. Higher toxicity is shown at 800 µg/mL.
Molecular Weight

3183.82

Formula

C₁₄₃H₂₂₆N₄₆O₃₃S₃

Sequence

Phe-Lys-Cys-Arg-Arg-Trp-Gln-Trp-Arg-Met-Lys-Lys-Leu-Gly-Ala-Pro-Ser-Ile-Thr-Cys-Val-Arg-Arg-Ala-Phe (Disulfide bridge: Cys3-Cys20)

Sequence Shortening

FKCRRWQWRMKKLGAPSITCVRRAF (Disulfide bridge: Cys3-Cys20)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Protect from light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (6.28 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3141 mL 1.5704 mL 3.1409 mL
5 mM 0.0628 mL 0.3141 mL 0.6282 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2 mg/mL (0.63 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2 mg/mL (0.63 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (0.63 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Lactoferrin (17-41) (acetate)
Cat. No.:
HY-P1791B
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