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  3. Lactoferrin (17-41) (acetate)

Lactoferrin (17-41) (acetate) (Synonyms: Lactoferricin B acetate; Lfcin B acetate)

Cat. No.: HY-P1791B
Handling Instructions

Lactoferrin 17-41 (Lactoferricin B) acetate, a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 acetate has antitumor activities.

For research use only. We do not sell to patients.

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Lactoferrin (17-41) (acetate) Chemical Structure

Lactoferrin (17-41) (acetate) Chemical Structure

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Description

Lactoferrin 17-41 (Lactoferricin B) acetate, a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 acetate has antitumor activities[1][2].

In Vitro

Lactoferrin 17-41 (Lactoferricin B) acetate has an MIC of 30 μg/ml against E. coli ATCC 25922[1].
Lactoferrin 17-41 acetate significantly stimulates apoptosis of HT-29 cells and displays cytotoxic activity on HT-29 cells[2].
Lactoferrin 17-41 acetate variously regulats transcription of genes involved in the p53 signaling pathway, such as PMAIP-1, TP5313, and SFN[2].
Lactoferrin 17-41 acetate can bind LPS from Gram-negative bacteria and that it can inhibit LPS induced cytokine response in human monocytic cells[1][3].

Cell Viability Assay[1]

Cell Line: HT-29 cells
Concentration: 50, 100, 200, 400, 800 or 1000 µg/mL
Incubation Time: 4, 12, 24 or 48 hours
Result: More effective at inducing apoptosis at 400 µg/mL. Higher toxicity is shown at 800 µg/mL.
Molecular Weight

3183.82

Formula

C₁₄₃H₂₂₆N₄₆O₃₃S₃

Sequence

Phe-Lys-Cys-Arg-Arg-Trp-Gln-Trp-Arg-Met-Lys-Lys-Leu-Gly-Ala-Pro-Ser-Ile-Thr-Cys-Val-Arg-Arg-Ala-Phe (Disulfide bridge: Cys3-Cys20)

Sequence Shortening

FKCRRWQWRMKKLGAPSITCVRRAF (Disulfide bridge: Cys3-Cys20)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Lactoferrin (17-41) (acetate)Lactoferricin BLfcin BBacterialFungalApoptosisantimicrobialGram-positiveantitumorcytotoxicHT-29cellsLPSp53pathwaycancerInhibitorinhibitorinhibit

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Lactoferrin (17-41) (acetate)
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HY-P1791B
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