Lactoferrin (17-41)
Based on 1 Customer Validation
Lactoferrin 17-41 (Lactoferricin B), a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 has antitumor activities.
For research use only. We do not sell to patients.
- Purity: 98.98%
- CAS No.: 146897-68-9
- Formula: C141H224N46O29S3
- Molecular Weight:3123.77
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Lactoferrin 17-41 (Lactoferricin B) has an MIC of 30 μg/ml against E. coli ATCC 25922[1].
Lactoferrin 17-41 significantly stimulates apoptosis of HT-29 cells and displays cytotoxic activity on HT-29 cells[2].
Lactoferrin 17-41 variously regulats transcription of genes involved in the p53 signaling pathway, such as PMAIP-1, TP5313, and SFN[2].
Lactoferrin 17-41 can bind LPS from Gram-negative bacteria and that it can inhibit LPS induced cytokine response in human monocytic cells[1][3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT-29 cells
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Concentration:50, 100, 200, 400, 800 or 1000 µg/mL
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Incubation Time:4, 12, 24 or 48 hours
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Result:More effective at inducing apoptosis at 400 µg/mL. Higher toxicity is shown at 800 µg/mL.
Chemical Information
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CAS No. 146897-68-9
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Appearance Solid
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Molecular Weight 3123.77
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Formula C141H224N46O29S3
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Color White to off-white
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Synonyms
Lactoferricin B; Lfcin B
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Sequence
Phe-Lys-Cys-Arg-Arg-Trp-Gln-Trp-Arg-Met-Lys-Lys-Leu-Gly-Ala-Pro-Ser-Ile-Thr-Cys-Val-Arg-Arg-Ala-Phe (Disulfide bridge: Cys3-Cys20)
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Sequence Shortening
FKCRRWQWRMKKLGAPSITCVRRAF (Disulfide bridge: Cys3-Cys20)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (263 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Samuelsen Ø, et al. Anti-complement effects of lactoferrin-derived peptides. FEMS Immunol Med Microbiol. 2004 Jun 1;41(2):141-8. [Content Brief]
[2]. Jiang R, et al. Bovine lactoferrin and lactoferricin exert antitumor activities on human colorectal cancer cells(HT-29) by activating various signaling pathways. Biochem Cell Biol. 2017 Feb;95(1):99-109. [Content Brief]
[3]. Latorre D, et al. Reciprocal interactions between lactoferrin and bacterial endotoxins and their role in the regulation of the immune response. Toxins (Basel). 2010;2(1):54‐68. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lactoferrin (17-41) Related Classifications
HY-P1791 Related Classifications
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