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Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity.

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No. CAS : 76343-94-7

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Revisión del cliente

Based on 6 publication(s) in Google Scholar

Other Forms of Latrunculin B:

Latrunculin B Related Antibodies

Top Publications Citing Use of Products

    Latrunculin B purchased from MedChemExpress. Usage Cited in: ACS Nano. 2026 Mar 10;20(9):7679-7692.

    Expression of Lamin A/C when hMSCs were treated with 20 μM Blebbistatin and 0.2 μM Latrunculin B adhering to C100, C70 and FLAT hydrogels. (a) The fluorescent images and (b) the quantification of Lamin A/C; the insets show the wrinkle generation on the nucleus after Blebbistatin and Latrunculin B treatment.

    Latrunculin B purchased from MedChemExpress. Usage Cited in: ACS Nano. 2026 Mar 10;20(9):7679-7692.

    Actin of hMSCs treated 0.2 μM Latrunculin B. (a) The fluorescent images and (b) the schematic illustration of expressed actin indicate Latrunculin B treatment inhibits actin fiber formation.

    Latrunculin B purchased from MedChemExpress. Usage Cited in: ACS Nano. 2026 Mar 10;20(9):7679-7692.

    The fluorescent images and surface area of hMSCs treated with 0.2 μM Latrunculin B.

    Latrunculin B purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jul 18;16(1):6621.  [Abstract]

    Latrunculin B (10 μM; pre-incubated for 10 min and then added with 20 μM monensin for 1 h) did not affect the formation of monensin-induced ATG8-positive invaginated vesicles in vacuoles.

    Latrunculin B purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Dec 27:e13632.  [Abstract]

    Latrunculin B (1 μM; 30 min) inhibited nuclear actin polymerization in TMZresistant GBM cells.

    Latrunculin B purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Dec 27:e13632.  [Abstract]

    Latrunculin B (1 μM; 30 min) significantly reduced the formation of nuclear F-actin in TMZ-resistant GBM cells compared to the DMSO-treated group. Immunofluorescence analysis of TMZ‐resistant GBM cells treated with Lifeact‐EGFP‐2xNLS plasmids after DMSO or LatB treatment.

    Latrunculin B purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Dec 27:e13632.  [Abstract]

    Latrunculin B (1 μM; 24 h) increased apoptosis in TMZ-resistant GBM cells treated with both TMZ and LatB.

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    Descripciòn

    Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity[1][2].

    Cellular Effect
    Cell Line Type Value Description References
    HCT-116 IC50
    7.1 μM
    Compound: 2, NSC-339663
    Cytotoxicity against human HCT116 cells after 3 days by trypan blue assay
    Cytotoxicity against human HCT116 cells after 3 days by trypan blue assay
    		[PMID: 18942825]
    HepG2 IC50
    19.27 μM
    Compound: 99b
    Anticancer activity against human HepG2 cells assessed as inhibition of cell growth
    Anticancer activity against human HepG2 cells assessed as inhibition of cell growth
    		[PMID: 33940466]
    HUVEC IC50
    478 nM
    Compound: LatB
    Inhibition of cell migration in human HUVEC cells assessed as decrease in cell velocity measured after 16 hrs by crystal violet staining based scratch assay
    Inhibition of cell migration in human HUVEC cells assessed as decrease in cell velocity measured after 16 hrs by crystal violet staining based scratch assay
    		[PMID: 31260301]
    HUVEC IC50
    611.6 nM
    Compound: LatB
    Antiproliferative activity against human HUVEC measured after 72 hrs
    Antiproliferative activity against human HUVEC measured after 72 hrs
    		[PMID: 31260301]
    MDA-MB-435 IC50
    4.8 μM
    Compound: 2, NSC-339663
    Cytotoxicity against human MDA-MB-435 cells 48 hrs by SRB assay
    Cytotoxicity against human MDA-MB-435 cells 48 hrs by SRB assay
    		[PMID: 18942825]
    In Vitro

    Latrunculin B displays growth inhibition of HeLa cells with an IC50 value of 1.4 μM[1].
    Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. Latrunculin B (100 nM) decreases the spontaneous electrical activity by 16±4% in pulmonary vein (PV) preparations. Latrunculin B (100 nM) decreases the late Na+ current, L-type Ca2+ current, Na+/Ca2+ exchanger current, and stretch-activated BKCa current in PV cardiomyocytes. Latrunculin B reduces the transient outward K+ current and ultra-rapid delayed rectifier K+ current, but increases the delayed rectifier K+ current in isolated PV cardiomyocytes. Latrunculin B (100 nM) decreases intracellular Ca2+ transient and sarcoplasmic reticulum Ca2+ content in PV cardiomyocytes. Latrunculin B attenuates stretch-induced increased spontaneous electrical activity and trigger activity[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Latrunculin B Related Antibodies
    Ensayo clínico
    Peso molecular

    395.51

    Fòrmula

    C20H29NO5S
    No. CAS
    Appearance

    Solid

    Color

    Colorless to off-white

    SMILES

    O=C1SC[C@@H]([C@]2(O)O[C@]3([H])CC[C@H](C)/C=C\CC/C(C)=C\C(O[C@@](C3)([H])C2)=O)N1
    Initial Source

    Red Sea sponge
    Envío

    Room temperature in continental US; may vary elsewhere.
    Almacenamiento
    Powder -20°C 3 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvente y solubilidad
    In Vitro: 

    DMSO : 25 mg/mL (63.21 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5284 mL 12.6419 mL 25.2838 mL
    5 mM 0.5057 mL 2.5284 mL 5.0568 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Pureza y Documentación

    Purity: 98.95%

    SDS (252 KB)

    COA (254 KB) HNMR (161 KB) RP-HPLC (153 KB)

    Instrucciones de manejo (2659 KB)
    Referencias

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.5284 mL 12.6419 mL 25.2838 mL 63.2095 mL
    5 mM 0.5057 mL 2.5284 mL 5.0568 mL 12.6419 mL
    10 mM 0.2528 mL 1.2642 mL 2.5284 mL 6.3210 mL
    15 mM 0.1686 mL 0.8428 mL 1.6856 mL 4.2140 mL
    20 mM 0.1264 mL 0.6321 mL 1.2642 mL 3.1605 mL
    25 mM 0.1011 mL 0.5057 mL 1.0114 mL 2.5284 mL
    30 mM 0.0843 mL 0.4214 mL 0.8428 mL 2.1070 mL
    40 mM 0.0632 mL 0.3160 mL 0.6321 mL 1.5802 mL
    50 mM 0.0506 mL 0.2528 mL 0.5057 mL 1.2642 mL
    60 mM 0.0421 mL 0.2107 mL 0.4214 mL 1.0535 mL
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    Latrunculin B Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Latrunculin B76343-94-7FungalantimicrobialmarinealkaloidactinpolymerizationpulmonaryveinelectrophysiologicalstretcharrhythmogenesisInhibitorinhibitorinhibit

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    Nombre del producto:
    Latrunculin B
    Cat. No.:
    HY-101848
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