2. Metabolic Enzyme/Protease
  3. Drug Metabolite Endogenous Metabolite
  4. Leukotriene D4

Leukotriene D4 is a potent bronchoconstrictor. Leukotriene D4 has the potential for the research of asthma. Leukotriene D4 induces edema and increases capillary permeability.

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Leukotriene D4

Leukotriene D4 Chemical Structure

CAS No. : 73836-78-9

Size Prix Stock Quantité
Solvent
10 μg (201.34 μM * 100 μL in Ethanol) En stock
Solvent
50 μg (201.34 μM * 500 μL in Ethanol) En stock

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Based on 3 publication(s) in Google Scholar

Other Forms of Leukotriene D4:

Leukotriene D4 Related Antibodies

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Human Endogenous Metabolite Microbial Metabolite

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Description

Leukotriene D4 is a potent bronchoconstrictor. Leukotriene D4 has the potential for the research of asthma. Leukotriene D4 induces edema and increases capillary permeability[1][2].

IC50 & Target

Human Endogenous Metabolite

 

Cellular Effect
Cell Line Type Value Description References
CHO-K1 IC50
0.7 nM
Compound: LTD4
Displacement of [3H]LTD4 from human recombinant cysteinyl leukotriene receptor 1 expressed in CHOK1 cells after 30 mins
Displacement of [3H]LTD4 from human recombinant cysteinyl leukotriene receptor 1 expressed in CHOK1 cells after 30 mins
[PMID: 23403082]
Sf9 IC50
5.48 μM
Compound: Leukotrien D4
TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cells
TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cells
[PMID: 11306690]
In Vivo

Leukotriene D4 (1.5, 3, 6, 12, 24 µg/paw; injected intradermally) causes edema and increases capillary permeability in a dose-related manner in mouse[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 21-24 g, Balb/c male mice[2]
Dosage: 1.5, 3, 6, 12, 24 µg/paw
Administration: Injected intradermally (10 µL was injected into the left hind paw)
Result: Caused significant edematous response and dye extravasation at doses of 1.5-6 ~g/paw.
Essai clinique
Masse moléculaire

496.66

Formule

C25H40N2O6S
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(O)CNC([C@H](CS[C@@H]([C@@H](O)CCCC(O)=O)/C=C/C=C/C=C\C/C=C\CCCCC)N)=O
Structure Classification
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Solution, -20°C, 2 years
Pureté et documentation

Purity: 98.5%

SDS (796 KB)

COA (242 KB)

Instruction de manipulation (2659 KB)
Références
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Leukotriene D4 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Leukotriene D473836-78-9Leukotriene D 4Leukotriene D-4Drug MetaboliteEndogenous Metaboliteasthmaedemacapillary permeabilityInhibitorinhibitorinhibit

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Cat. No.:
HY-113456
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