2. Metabolic Enzyme/Protease
  3. HMG-CoA Reductase (HMGCR)
  4. Lovastatin hydroxy acid sodium

Lovastatin hydroxy acid sodium  (Synonyms: Mevinolinic acid sodium)

Cat. No.: HY-123672 Purity: 99.50%
COA
SDS
Handling Instructions Technical Support

Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM.

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Lovastatin hydroxy acid sodium

Lovastatin hydroxy acid sodium 화학구조

CAS No. : 75225-50-2

사이즈 가격 재고 수량
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg   견적 받기  
100 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Other Forms of Lovastatin hydroxy acid sodium:

Lovastatin hydroxy acid sodium Related Antibodies

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  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM[1].

IC50 & Target

Ki: 0.6 nM (HMG-CoA reductase)[1]
Cellular Effect
Cell Line Type Value Description References
HES IC50
17 1
Compound: mevinolin (salt)
Concentration required to inhibit HMG-CoA reductase by 50% was determined in HES 9 cell line
Concentration required to inhibit HMG-CoA reductase by 50% was determined in HES 9 cell line
[PMID: 1527791]
HepG2 IC50
29 1
Compound: mevinolin (salt)
Concentration required to inhibit HMG-CoA reductase by 50% was determined in Hep G2 cell line
Concentration required to inhibit HMG-CoA reductase by 50% was determined in Hep G2 cell line
[PMID: 1527791]
HES IC50
17 1
Compound: mevinolin (salt)
Concentration required to inhibit HMG-CoA reductase by 50% was determined in HES 9 cell line
Concentration required to inhibit HMG-CoA reductase by 50% was determined in HES 9 cell line
[PMID: 1527791]
HepG2 IC50
29 1
Compound: mevinolin (salt)
Concentration required to inhibit HMG-CoA reductase by 50% was determined in Hep G2 cell line
Concentration required to inhibit HMG-CoA reductase by 50% was determined in Hep G2 cell line
[PMID: 1527791]
Hepatocyte IC50
0.146 3
Compound: 1b
Compound was tested for 50% inhibition of cholesterol synthesis in isolated rat hepatocytes.
Compound was tested for 50% inhibition of cholesterol synthesis in isolated rat hepatocytes.
[PMID: 2231594]
HES IC50
17 1
Compound: mevinolin (salt)
Concentration required to inhibit HMG-CoA reductase by 50% was determined in HES 9 cell line
Concentration required to inhibit HMG-CoA reductase by 50% was determined in HES 9 cell line
[PMID: 1527791]
Hepatocyte IC50
0.146 3
Compound: 1b
Compound was tested for 50% inhibition of cholesterol synthesis in isolated rat hepatocytes.
Compound was tested for 50% inhibition of cholesterol synthesis in isolated rat hepatocytes.
[PMID: 2231594]
HepG2 IC50
29 1
Compound: mevinolin (salt)
Concentration required to inhibit HMG-CoA reductase by 50% was determined in Hep G2 cell line
Concentration required to inhibit HMG-CoA reductase by 50% was determined in Hep G2 cell line
[PMID: 1527791]
In Vitro

Mevinolin in the hydroxy-acid form, mevinolinic acid, is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase [mevalonate: NADP+ oxidoreductase (CoA-acylating)][1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lovastatin hydroxy acid sodium Related Antibodies
분자량

444.54

화학식

C24H37NaO6
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(C[C@@H](C[C@@H](CC[C@H]1[C@H](C=CC2=C[C@@H](C[C@@H]([C@]12[H])OC([C@H](CC)C)=O)C)C)O)O)O[Na]
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도
In Vitro: 

DMSO : 12.5 mg/mL (28.12 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 12.5 mg/mL (28.12 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2495 mL 11.2476 mL 22.4952 mL
5 mM 0.4499 mL 2.2495 mL 4.4990 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 99.50%

SDS (394 KB)

COA (250 KB) Elemental Analysis Report (108 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.2495 mL 11.2476 mL 22.4952 mL 56.2379 mL
5 mM 0.4499 mL 2.2495 mL 4.4990 mL 11.2476 mL
10 mM 0.2250 mL 1.1248 mL 2.2495 mL 5.6238 mL
15 mM 0.1500 mL 0.7498 mL 1.4997 mL 3.7492 mL
20 mM 0.1125 mL 0.5624 mL 1.1248 mL 2.8119 mL
25 mM 0.0900 mL 0.4499 mL 0.8998 mL 2.2495 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Lovastatin hydroxy acid sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lovastatin hydroxy acid75225-50-2Mevinolinic acidHMG-CoA Reductase (HMGCR)CholesterolLoweringAgentHMG-CoAreductaseInhibitorinhibitorinhibit

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상품명:
Lovastatin hydroxy acid sodium
Cat. No.:
HY-123672
수량:
MCE Japan Authorized Agent:

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SAFETY DATA SHEET (SDS)

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