2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. Lu AA33810

Lu AA33810 is a selective, orally active and brain-penetrant antagonist of neuropeptide Y5 receptor with a Ki of 1.5 nM for the rat receptor. Lu AA33810 exhibts antianxiolytic-like and antidepressant-like effects.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Lu AA33810

Lu AA33810 Chemische Struktur

CAS. Nr. : 304008-29-5

Größe Preis Verfügbarkeit Menge
1 mg Auf Lager
5 mg Auf Lager
10 mg Auf Lager
50 mg   Angebot einholen  
100 mg   Angebot einholen  

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

This product is a controlled substance and not for sale in your territory.

Kundenbewertung

Based on 1 Customer Validation

Lu AA33810 Related Antibodies

Top Publications Citing Use of Products

Alle Neuropeptide Y Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
NPY Y1 receptor NPY Y2 receptor NPY Y4 receptor NPY Y5 receptor

  • Biologische Aktivität

  • Reinheit & Dokumentation

  • Verweise

  • Kundenbewertung

Beschreibung

Lu AA33810 is a selective, orally active and brain-penetrant antagonist of neuropeptide Y5 receptor with a Ki of 1.5 nM for the rat receptor. Lu AA33810 exhibts antianxiolytic-like and antidepressant-like effects[1][2].

IC50 & Target

hY5 receptor

1.5 nM (Ki)

In Vitro

Lu AA33810 antagonizes NPY-evoked cAMP and calcium mobilization in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lu AA33810 Related Antibodies
In Vivo

In Sprague-Dawley rats subjected to the social interaction test, Lu AA33810 (3-30 mg/kg p.o.) produces anxiolytic-like effects after acute or chronic treatment[1].
In Flinders sensitive line rats, chronic dosing of Lu AA33810 (10 mg/kg/day i.p.) produces anxiolytic-like effects in the social interaction test, plus antidepressant-like effects in the forced swim test[1].
In Wistar rats exposed to chronic mild stress, chronic dosing of Lu AA33810 (3 and 10 mg/kg/day i.p.) produces antidepressant-like activity, i.e., normalization of stress-induced decrease in sucrose consumption[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molekulargewicht

423.62

Formel

C19H25N3O2S3
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

CS(NC[C@@H](CC1)CC[C@H]1NC2=NC3=C(S2)CCSC4=CC=CC=C34)(=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 42.36 mg/mL (100.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3606 mL 11.8030 mL 23.6061 mL
5 mM 0.4721 mL 2.3606 mL 4.7212 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3606 mL 11.8030 mL 23.6061 mL 59.0152 mL
5 mM 0.4721 mL 2.3606 mL 4.7212 mL 11.8030 mL
10 mM 0.2361 mL 1.1803 mL 2.3606 mL 5.9015 mL
15 mM 0.1574 mL 0.7869 mL 1.5737 mL 3.9343 mL
20 mM 0.1180 mL 0.5902 mL 1.1803 mL 2.9508 mL
25 mM 0.0944 mL 0.4721 mL 0.9442 mL 2.3606 mL
30 mM 0.0787 mL 0.3934 mL 0.7869 mL 1.9672 mL
40 mM 0.0590 mL 0.2951 mL 0.5902 mL 1.4754 mL
50 mM 0.0472 mL 0.2361 mL 0.4721 mL 1.1803 mL
60 mM 0.0393 mL 0.1967 mL 0.3934 mL 0.9836 mL
80 mM 0.0295 mL 0.1475 mL 0.2951 mL 0.7377 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Lu AA33810 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lu AA33810304008-29-5Lu AA 33810Lu AA-33810Neuropeptide Y ReceptorNPY receptororally activeneuropeptide Y5 receptorantianxiolytic-like and antidepressant-like effectsInhibitorinhibitorinhibit

Ihre kürzlich angesehenen Produkte:

Online-Anfrage

Your information is safe with us. * Required Fields.

Produktname

  

Requested Quantity *

Name des Antragstellers *

 

Anrede

E-Mail-Addresse *

 

Telefonnummer *

Department

 

Name der Organisation *

City

Bundesland

Country or Region *

      

Bemerkungen

Massenanfrage

Inquiry Information

Produktname:
Lu AA33810
Art. -Nr.:
HY-107729
Menge:
MCE Japan Authorized Agent:

Kundenbewertung

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Produktname

  

Lot #

Name des Antragstellers *

 

E-Mail-Addresse *

Telefonnummer

 

Department *

Name der Organisation *

 

Country or Region *

Bemerkungen

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.