2. Apoptosis
  3. Bcl-2 Family Apoptosis
  4. Mcl-1-IN-22 hydrochloride

Mcl-1-IN-22 hydrochloride is a tetrahydro-β-carboline-based Mcl-1 inhibitor with a Ki of 0.015 μM. Mcl-1-IN-22 hydrochloride shows antitumor activity, induces apoptosis and produces synergistic antitumor effects in combination with Cisplatin (HY-17394) and Paclitaxel (HY-B0015). Mcl-1-IN-22 hydrochloride can be used for the research of cancer, such as ovarian cancer.

For research use only. We do not sell to patients.

Mcl-1-IN-22 hydrochloride

Mcl-1-IN-22 hydrochloride Chemical Structure

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Other Forms of Mcl-1-IN-22 hydrochloride:

Mcl-1-IN-22 hydrochloride Related Antibodies

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Description

Mcl-1-IN-22 hydrochloride is a tetrahydro-β-carboline-based Mcl-1 inhibitor with a Ki of 0.015 μM. Mcl-1-IN-22 hydrochloride shows antitumor activity, induces apoptosis and produces synergistic antitumor effects in combination with Cisplatin (HY-17394) and Paclitaxel (HY-B0015). Mcl-1-IN-22 hydrochloride can be used for the research of cancer, such as ovarian cancer[1].

IC50 & Target[1]

Mcl-1

0.015 μM (Ki)

In Vitro

The active component (Compound N5) of Mcl-1-IN-22 hydrochloride (Compound N5Y) inhibits Mcl-1 with a Ki of 0.015 μM, exhibits anti-tumor activity against various cancer cells, and induces apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mcl-1-IN-22 hydrochloride Related Antibodies
Parmacokinetics
Species Dose Route F T1/2 Tmax AUC0-t MRT0-t Cmax
Rat[1] 30 mg/kg i.v. / 3.77 h / 5230.50 ng·h/mL 2.28 h 8562.14 ng/mL
Rat[1] 100 mg/kg p.o. 26.02 % 4.24 h 0.5 h 4536.5 ng·h/mL 2.61 h /
In Vivo

Mcl-1-IN-22 hydrochloride (Compound N5Y) (30 mg/kg; i.v.; daily; 14 days) inhibits tumorg rowth in A2780S ovarian cancer xenografts mice models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ovarian cancer Balb/c nude mice (female, 5 weeks old, 16-18 g, subcutaneous xenograft of A2780S cells)[1]
Dosage: 30 mg/kg
Administration: i.v.; daily; 14 days; i.v.; every other day; 14 days (combination with cisplatin i.p.; every other day; 14 days, alternate dosing)
Result: Achieved a tumor growth inhibition (TGI) of 53.2% and a tumor volume T/C ratio of 49.3%.
Showed synergistic antitumor effect with Cisplatin (HY-17394) and Paclitaxel (HY-B0015).
Caused no significant body weight loss or increased toxicity relative to cisplatin alone.
Molecular Weight

554.51

Formula

C30H33Cl2N3O3
SMILES

O=C(C1=CC(CN(C2)CCC3=C2N(CCCOC4=CC(C)=C(Cl)C(C)=C4)C5=C3C=CC=C5)=CC=C1)NO.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Mcl-1-IN-22 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mcl-1-IN-22Bcl-2 FamilyApoptosisA2780S ovarian cancer xenograftscancer modelscisplatin resistancecisplatin-resistant ovarian cancerpaclitaxelovarian cancercisplatinMcl-1cancer cellsA2780/CDDP ovarian cancer xenograftsInhibitorinhibitorinhibit

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