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Cat. No.: HY-183601A

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Mcl-1-IN-22 hydrochloride

Mcl-1-IN-22 hydrochloride is a tetrahydro-β-carboline-based Mcl-1 inhibitor with a K_i of 0.015 μM. Mcl-1-IN-22 hydrochloride shows antitumor activity, induces apoptosis and produces synergistic antitumor effects in combination with Cisplatin (HY-17394) and Paclitaxel (HY-B0015). Mcl-1-IN-22 hydrochloride can be used for the research of cancer, such as ovarian cancer.

For research use only. We do not sell to patients.

Formula: C₃₀H₃₃Cl₂N₃O₃
Molecular Weight:554.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Mcl-1-IN-22 hydrochloride Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target^[1]

Mcl-1

0.015 μM (Ki)

All Bcl-2 Family Isoforms :

In Vitro

The active component (HY-183601) of Mcl-1-IN-22 hydrochloride (Compound N5Y) inhibits Mcl-1 with a K_i of 0.015 μM, exhibits anti-tumor activity against various cancer cells, and induces apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	F	T_1/2	T_max	AUC_0-t	MRT_0-t	C_max
Rat^[1]	30 mg/kg	i.v.	/	3.77 h	/	5230.50 ng·h/mL	2.28 h	8562.14 ng/mL
Rat^[1]	100 mg/kg	p.o.	26.02 %	4.24 h	0.5 h	4536.5 ng·h/mL	2.61 h	/

In Vivo

Mcl-1-IN-22 hydrochloride (Compound N5Y) (30 mg/kg; i.v.; daily; 14 days) inhibits tumorg rowth in A2780S ovarian cancer xenografts mice models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Ovarian cancer Balb/c nude mice (female, 5 weeks old, 16-18 g, subcutaneous xenograft of A2780S cells)^[1]
Dosage:

30 mg/kg
Administration:

i.v.; daily; 14 days; i.v.; every other day; 14 days (combination with cisplatin i.p.; every other day; 14 days, alternate dosing)
Result:

Achieved a tumor growth inhibition (TGI) of 53.2% and a tumor volume T/C ratio of 49.3%.
Showed synergistic antitumor effect with Cisplatin (HY-17394) and Paclitaxel (HY-B0015).
Caused no significant body weight loss or increased toxicity relative to cisplatin alone.

Chemical Information

Molecular Weight 554.51
Formula C₃₀H₃₃Cl₂N₃O₃
SMILES

O=C(C1=CC(CN(C2)CCC3=C2N(CCCOC4=CC(C)=C(Cl)C(C)=C4)C5=C3C=CC=C5)=CC=C1)NO.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ning DY, et al. Discovery of a Novel Tetrahydro-β-Carboline Mcl-1 Inhibitor with Antitumor Activity and Capability to Overcome Cisplatin Resistance. J Med Chem. 2026;69(9):10621-10646. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Mcl-1-IN-22 hydrochloride

All Bcl-2 Family Isoforms