2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Methoctramine

Methoctramine is a potent and cardioselectivity antagonist of M2 muscarinic receptor. Methoctramine can inhibit Muscarine (HY-121404)-induced bradycardia in vivo. Methoctramine can be used in the study of cardiovascular diseases.

For research use only. We do not sell to patients.

Methoctramine

Methoctramine Chemical Structure

CAS No. : 104807-40-1

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Methoctramine:

Other Forms of Methoctramine:

Methoctramine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Methoctramine

View All mAChR Isoform Specific Products:

View All Isoforms
mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Methoctramine is a potent and cardioselectivity antagonist of M2 muscarinic receptor. Methoctramine can inhibit Muscarine (HY-121404)-induced bradycardia in vivo. Methoctramine can be used in the study of cardiovascular diseases[1].

Cellular Effect
Cell Line Type Value Description References
Astrocyte EC50
0.0845 3
Compound: 31
Antiproliferative activity against mouse astrocyte cells by MTT assay
Antiproliferative activity against mouse astrocyte cells by MTT assay
[PMID: 17417631]
Astrocyte EC50
0.0845 3
Compound: 31
Antiproliferative activity against mouse astrocyte cells by MTT assay
Antiproliferative activity against mouse astrocyte cells by MTT assay
[PMID: 17417631]
HeLa IC50
>100 3
Compound: 1, methoctramine
Cytotoxicity against human HeLa cells assessed as cell survival after 24 hrs by trypan blue exclusion assay
Cytotoxicity against human HeLa cells assessed as cell survival after 24 hrs by trypan blue exclusion assay
[PMID: 23887056]
Oocyte IC50
138 1
Compound: 1
Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-induced inward current at -70mV by two-electrode voltage clamp assay
Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-induced inward current at -70mV by two-electrode voltage clamp assay
[PMID: 23692871]
Thymocyte IC50
>100 3
Compound: 1, methoctramine
Cytotoxicity against rat thymocytes assessed as cell survival after 24 hrs by trypan blue exclusion assay
Cytotoxicity against rat thymocytes assessed as cell survival after 24 hrs by trypan blue exclusion assay
[PMID: 23887056]
Molecular Weight

582.90

Formula

C36H62N4O2
CAS No.
SMILES

COC1=CC=CC=C1CNCCCCCCNCCCCCCCCNCCCCCCNCC2=CC=CC=C2OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Methoctramine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methoctramine104807-40-1mAChRMuscarinic acetylcholine receptorM2muscarinicbradycardiaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Methoctramine
Cat. No.:
HY-116294
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.