Muscarine
Based on 1 publication(s) in Google Scholar
Muscarine ((+)-Muscarine) is an agonist of prototype mAChR. Muscarine is a toxin that can stimulate the parasympathetic nervous system.
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- CAS 番号: 300-54-9
- 分子式: C9H20NO2+
- 分子量:174.26
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Muscarine
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生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
130 nM
Compound: Muscarine
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Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M3
Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M3
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[PMID: 9622546] |
| CHO | EC50 |
219 nM
Compound: Muscarine
|
Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M1
Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M1
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[PMID: 9622546] |
| CHO | IC50 |
0.49 μM
Compound: Muscarine
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Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP
Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP
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[PMID: 9622546] |
| CHO | IC50 |
3.9 μM
Compound: Muscarine
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Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP
Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP
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[PMID: 9622546] |
| CHO | IC50 |
470 nM
Compound: Muscarine
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Inhibitory activity against [3H]-cyclic AMP accumulation in CHO transfected cells mediated by Muscarinic acetylcholine receptor M4
Inhibitory activity against [3H]-cyclic AMP accumulation in CHO transfected cells mediated by Muscarinic acetylcholine receptor M4
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[PMID: 9622546] |
体外実験
Muscarine (100 µM) induces an intracellular calcium signal amplitude similar to the one triggered by 10 µM acetylcholine in brain miero vascular endothelial cells (BMVECs) and brain-derived Endothelial cells.3 (bEnd.3)[1].
Muscarine (1-30 μM; 2 min) produces a dose-dependent hyperpolarization in a sub-population of the nucleus raphe magnus (NRM) cells that contain 5-hydroxytryptamine (5-HT) on the NRM neurons with an EC50 value of 2.7 µM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 300-54-9
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分子量 174.26
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分子式 C9H20NO2+
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SMILES
C[C@H]1[C@@H](C[C@H](O1)C[N+](C)(C)C)O
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別名
(+)-Muscarine
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Cancer Cell
2025 Nov 10;43(11):2089-2105.e10. PMID: 40829591
純度とドキュメンテーション
参考文献
[1]. Beatrice Mihaela Radu, et al. All muscarinic acetylcholine receptors (M 1-M 5) are expressed in murine brain microvascular endothelium. Sci Rep. 2017 Jul 11;7(1):5083. [Content Brief]
[2]. Z Z Pan, et al. Muscarine hyperpolarizes a subpopulation of neurons by activating an M2 muscarinic receptor in rat nucleus raphe magnus in vitro. J Neurosci. 1994 Mar;14(3 Pt 1):1332-8. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Muscarine 関連分類
HY-121404 関連分類
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