Muscarine chloride  (Synonyms: (+)-Muscarine chloride)

Muscarine ((+)-Muscarine) chloride is an agonist of prototype mAChR. Muscarine chloride is a toxin that can stimulate the parasympathetic nervous system^[1][2].

Muscarine chloride (100 µM) induces an intracellular calcium signal amplitude similar to the one triggered by 10 µM acetylcholine in brain miero vascular endothelial cells (BMVECs) and brain-derived Endothelial cells.3 (bEnd.3)^[1].
Muscarine chloride (1-30 μM; 2 min) produces a dose-dependent hyperpolarization in a sub-population of the nucleus raphe magnus (NRM) cells that contain 5-hydroxytryptamine (5-HT) on the NRM neurons with an EC₅₀ value of 2.7 µM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

209.71

C₉H₂₀ClNO₂

2303-35-7

Solid

White to off-white

C[C@H]1[C@@H](C[C@H](O1)C[N+](C)(C)C)O.[Cl-]

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Beatrice Mihaela Radu, et al. All muscarinic acetylcholine receptors (M 1-M 5) are expressed in murine brain microvascular endothelium. Sci Rep. 2017 Jul 11;7(1):5083.  [Content Brief]

  [2]. Z Z Pan, et al. Muscarine hyperpolarizes a subpopulation of neurons by activating an M2 muscarinic receptor in rat nucleus raphe magnus in vitro. J Neurosci. 1994 Mar;14(3 Pt 1):1332-8.  [Content Brief]