Muscarine chloride
Based on 1 publication(s) in Google Scholar
Muscarine ((+)-Muscarine) chloride is an agonist of prototype mAChR. Muscarine chloride is a toxin that can stimulate the parasympathetic nervous system.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 2303-35-7
- Formula: C9H20ClNO2
- Molecular Weight:209.71
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Muscarine chloride
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
1 μM
Compound: muscarine chloride
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Activation of M3-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signal
Activation of M3-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signal
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[PMID: 20716489] |
| HEK293 | EC50 |
1.3 μM
Compound: muscarine chloride
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Activation of M5-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signal
Activation of M5-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signal
|
[PMID: 20716489] |
| HEK293 | EC50 |
5.3 μM
Compound: muscarine chloride
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Activation of M1-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signal
Activation of M1-ACh receptor-FLASH/CFP expressed in HEK293 cells assessed as FRET signal
|
[PMID: 20716489] |
Muscarine chloride (100 µM) induces an intracellular calcium signal amplitude similar to the one triggered by 10 µM acetylcholine in brain miero vascular endothelial cells (BMVECs) and brain-derived Endothelial cells.3 (bEnd.3)[1]. Muscarine chloride (1-30 μM; 2 min) produces a dose-dependent hyperpolarization in a sub-population of the nucleus raphe magnus (NRM) cells that contain 5-hydroxytryptamine (5-HT) on the NRM neurons with an EC50 value of 2.7 µM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2303-35-7
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Appearance Solid
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Molecular Weight 209.71
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Formula C9H20ClNO2
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Color White to off-white
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SMILES
C[C@H]1[C@@H](C[C@H](O1)C[N+](C)(C)C)O.[Cl-]
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Synonyms
(+)-Muscarine chloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Cancer Cell
2025 Nov 10;43(11):2089-2105.e10. PMID: 40829591
Solvent & Solubility
H2O : 50 mg/mL (238.42 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
[1]. Beatrice Mihaela Radu, et al. All muscarinic acetylcholine receptors (M 1-M 5) are expressed in murine brain microvascular endothelium. Sci Rep. 2017 Jul 11;7(1):5083. [Content Brief]
[2]. Z Z Pan, et al. Muscarine hyperpolarizes a subpopulation of neurons by activating an M2 muscarinic receptor in rat nucleus raphe magnus in vitro. J Neurosci. 1994 Mar;14(3 Pt 1):1332-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.7685 mL | 23.8424 mL | 47.6849 mL | 119.2122 mL |
| 5 mM | 0.9537 mL | 4.7685 mL | 9.5370 mL | 23.8424 mL | |
| 10 mM | 0.4768 mL | 2.3842 mL | 4.7685 mL | 11.9212 mL | |
| 15 mM | 0.3179 mL | 1.5895 mL | 3.1790 mL | 7.9475 mL | |
| 20 mM | 0.2384 mL | 1.1921 mL | 2.3842 mL | 5.9606 mL | |
| 25 mM | 0.1907 mL | 0.9537 mL | 1.9074 mL | 4.7685 mL | |
| 30 mM | 0.1589 mL | 0.7947 mL | 1.5895 mL | 3.9737 mL | |
| 40 mM | 0.1192 mL | 0.5961 mL | 1.1921 mL | 2.9803 mL | |
| 50 mM | 0.0954 mL | 0.4768 mL | 0.9537 mL | 2.3842 mL | |
| 60 mM | 0.0795 mL | 0.3974 mL | 0.7947 mL | 1.9869 mL | |
| 80 mM | 0.0596 mL | 0.2980 mL | 0.5961 mL | 1.4902 mL | |
| 100 mM | 0.0477 mL | 0.2384 mL | 0.4768 mL | 1.1921 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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