Methoctramine tetrahydrochloride
Based on 1 publication(s) in Google Scholar
Methoctramine tetrahydrochloride is a potent and cardioselectivity antagonist of M2 muscarinic receptor. Methoctramine tetrahydrochloride can inhibit Muscarine (HY-121404)-induced bradycardia in vivo. Methoctramine tetrahydrochloride can be used in the study of cardiovascular diseases.
For research use only. We do not sell to patients.
- Purity: 98.72%
- CAS No.: 104807-46-7
- Formula: C36H66Cl4N4O2
- Molecular Weight:728.75
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Methoctramine tetrahydrochloride
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Biological Activity
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mAChR2 |
Methoctramine tetrahydrochloride attenuates Acetylcholine (ACh)- and Arecaidine propargyl ester (APE)-induced increases in PG synthesis in a concentration-dependent manner[1].
Methoctramine (0.01-1 μM) tetrahydrochloride causes facilitation of contractions induced by both pre- and postganglionic nerve stimulation in the guinea-pig isolated, innervated tracheal tube preparation[2].
Methoctramine (≥10 μM) tetrahydrochloride reduces responses to both nerve stimulation and exogenous ACh[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 104807-46-7
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Appearance Solid
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Molecular Weight 728.75
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Formula C36H66Cl4N4O2
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Color White to off-white
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SMILES
COC1=C(C=CC=C1)CNCCCCCCNCCCCCCCCNCCCCCCNCC2=C(C=CC=C2)OC.Cl.Cl.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Pharmaceuticals (Basel)
Ethanolic Extracts of Cupressaceae Species Conifers Provide Rapid Protection against Barium Chloride-Induced Cardiac Arrhythmia. [Abstract]2024 Jul 29;17(8):1003. PMID: 39204108
Solvent & Solubility
H2O : ≥ 100 mg/mL (137.22 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Jaiswal N, et, al. Methoctramine, a cardioselective antagonist: muscarinic receptor mediating prostaglandin synthesis in isolated rabbit heart. Eur J Pharmacol. 1991 Jan 3;192(1):63-70. [Content Brief]
[2]. Watson N, et, al. Actions of methoctramine, a muscarinic M2 receptor antagonist, on muscarinic and nicotinic cholinoceptors in guinea-pig airways in vivo and in vitro. Br J Pharmacol. 1992 Jan;105(1):107-12. [Content Brief]
[3]. Wess J, et, al. Methoctramine selectively blocks cardiac muscarinic M2 receptors in vivo. Naunyn Schmiedebergs Arch Pharmacol. 1988 Sep;338(3):246-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.3722 mL | 6.8611 mL | 13.7221 mL | 34.3053 mL |
| 5 mM | 0.2744 mL | 1.3722 mL | 2.7444 mL | 6.8611 mL | |
| 10 mM | 0.1372 mL | 0.6861 mL | 1.3722 mL | 3.4305 mL | |
| 15 mM | 0.0915 mL | 0.4574 mL | 0.9148 mL | 2.2870 mL | |
| 20 mM | 0.0686 mL | 0.3431 mL | 0.6861 mL | 1.7153 mL | |
| 25 mM | 0.0549 mL | 0.2744 mL | 0.5489 mL | 1.3722 mL | |
| 30 mM | 0.0457 mL | 0.2287 mL | 0.4574 mL | 1.1435 mL | |
| 40 mM | 0.0343 mL | 0.1715 mL | 0.3431 mL | 0.8576 mL | |
| 50 mM | 0.0274 mL | 0.1372 mL | 0.2744 mL | 0.6861 mL | |
| 60 mM | 0.0229 mL | 0.1144 mL | 0.2287 mL | 0.5718 mL | |
| 80 mM | 0.0172 mL | 0.0858 mL | 0.1715 mL | 0.4288 mL | |
| 100 mM | 0.0137 mL | 0.0686 mL | 0.1372 mL | 0.3431 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Methoctramine tetrahydrochloride Related Classifications
HY-116294A Related Classifications
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