2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Methoctramine tetrahydrochloride

Methoctramine tetrahydrochloride is a potent and cardioselectivity antagonist of M2 muscarinic receptor. Methoctramine tetrahydrochloride can inhibit Muscarine (HY-121404)-induced bradycardia in vivo. Methoctramine tetrahydrochloride can be used in the study of cardiovascular diseases.

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Methoctramine tetrahydrochloride

Methoctramine tetrahydrochloride Chemical Structure

CAS No. : 104807-46-7

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Methoctramine tetrahydrochloride:

Methoctramine tetrahydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Methoctramine tetrahydrochloride

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Methoctramine tetrahydrochloride is a potent and cardioselectivity antagonist of M2 muscarinic receptor. Methoctramine tetrahydrochloride can inhibit Muscarine (HY-121404)-induced bradycardia in vivo. Methoctramine tetrahydrochloride can be used in the study of cardiovascular diseases[1][2][3].

IC50 & Target

mAChR2

 

In Vitro

Methoctramine tetrahydrochloride attenuates Acetylcholine (ACh)- and Arecaidine propargyl ester (APE)-induced increases in PG synthesis in a concentration-dependent manner[1].
Methoctramine (0.01-1 μM) tetrahydrochloride causes facilitation of contractions induced by both pre- and postganglionic nerve stimulation in the guinea-pig isolated, innervated tracheal tube preparation[2].
Methoctramine (≥10 μM) tetrahydrochloride reduces responses to both nerve stimulation and exogenous ACh[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Methoctramine tetrahydrochloride Related Antibodies
In Vivo

Methoctramine (300 μg/kg; i.v.) tetrahydrochloride strongly inhibits the Methacholine- and Muscarine-induced bradycardia in the anaesthetized rat, respectively[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

728.75

Formula

C36H66Cl4N4O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=C(C=CC=C1)CNCCCCCCNCCCCCCCCNCCCCCCNCC2=C(C=CC=C2)OC.Cl.Cl.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (137.22 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3722 mL 6.8611 mL 13.7221 mL
5 mM 0.2744 mL 1.3722 mL 2.7444 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.72%

SDS (252 KB)

COA (241 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3722 mL 6.8611 mL 13.7221 mL 34.3053 mL
5 mM 0.2744 mL 1.3722 mL 2.7444 mL 6.8611 mL
10 mM 0.1372 mL 0.6861 mL 1.3722 mL 3.4305 mL
15 mM 0.0915 mL 0.4574 mL 0.9148 mL 2.2870 mL
20 mM 0.0686 mL 0.3431 mL 0.6861 mL 1.7153 mL
25 mM 0.0549 mL 0.2744 mL 0.5489 mL 1.3722 mL
30 mM 0.0457 mL 0.2287 mL 0.4574 mL 1.1435 mL
40 mM 0.0343 mL 0.1715 mL 0.3431 mL 0.8576 mL
50 mM 0.0274 mL 0.1372 mL 0.2744 mL 0.6861 mL
60 mM 0.0229 mL 0.1144 mL 0.2287 mL 0.5718 mL
80 mM 0.0172 mL 0.0858 mL 0.1715 mL 0.4288 mL
100 mM 0.0137 mL 0.0686 mL 0.1372 mL 0.3431 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Methoctramine tetrahydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methoctramine tetrahydrochloride104807-46-7mAChRMuscarinic acetylcholine receptorM2muscarinicbradycardiaInhibitorinhibitorinhibit

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