104807-46-7
Chemical Structure
Methoctramine tetrahydrochloride
- CAS No.: 104807-46-7
- Formula:C36H66Cl4N4O2
- Molecular Weight:728.75
IUPAC Name: N1,N1'-(octane-1,8-diyl)bis(N6-(2-methoxybenzyl)hexane-1,6-diamine) tetrahydrochloride
InChIKey: CDKGGOUDHGSFAF-UHFFFAOYSA-N
SMILES: COC1=C(C=CC=C1)CNCCCCCCNCCCCCCCCNCCCCCCNCC2=C(C=CC=C2)OC.Cl.Cl.Cl.Cl
Biological Activity: Methoctramine tetrahydrochloride is a potent and cardioselectivity antagonist of M2 muscarinic receptor. Methoctramine tetrahydrochloride can inhibit Muscarine (HY-121404)-induced bradycardia in vivo. Methoctramine tetrahydrochloride can be used in the study of cardiovascular diseases[1][2][3].
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Methoctramine tetrahydrochloride | 98.72% | Methoctramine tetrahydrochloride is a potent and cardioselectivity antagonist of M2 muscarinic receptor. Methoctramine tetrahydrochloride can inhibit Muscarine (HY-121404)-induced bradycardia in vivo. Methoctramine tetrahydrochloride can be used in the study of cardiovascular diseases. | ||||||||||||||||||||
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- [1]. Jaiswal N, et, al. Methoctramine, a cardioselective antagonist: muscarinic receptor mediating prostaglandin synthesis in isolated rabbit heart. Eur J Pharmacol. 1991 Jan 3;192(1):63-70. [Content Brief]
- [2]. Watson N, et, al. Actions of methoctramine, a muscarinic M2 receptor antagonist, on muscarinic and nicotinic cholinoceptors in guinea-pig airways in vivo and in vitro. Br J Pharmacol. 1992 Jan;105(1):107-12. [Content Brief]
- [3]. Wess J, et, al. Methoctramine selectively blocks cardiac muscarinic M2 receptors in vivo. Naunyn Schmiedebergs Arch Pharmacol. 1988 Sep;338(3):246-9. [Content Brief]
Keywords
