Methyl Salicylate-d₄  (Synonyms: Wintergreen oil-d₄)

Methyl Salicylate-d₄ is the deuterium labeled Methyl Salicylate^[1]. Methyl Salicylate (Wintergreen oil) is a topical analgesic and anti-inflammatory agent. Also used as a pesticide, a denaturant, a fragrance ingredient, and a flavoring agent in food and tobacco products^[2]. A systemic acquired resistance (SAR) signal in tobacco^[3]. A topical nonsteroidal anti-inflammatory agent (NSAID). Methyl salicylate lactoside is a COX inhibitor^[5].

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

156.17

C₈H₄D₄O₃

1219802-12-6

119-36-8

Liquid (Density: 1.210±0.06 g/cm³)

Colorless to light yellow

COC(C1=C(C([2H])=C([2H])C([2H])=C1[2H])O)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]

  [2]. Greene T, et al. A critical review of the literature to conduct a toxicity assessment for oral exposure to methyl salicylate. Crit Rev Toxicol. 2017 Feb;47(2):98-120.  [Content Brief]

  [3]. Park SW, et al. Methyl salicylate is a critical mobile signal for plant systemic acquired resistance. Science. 2007 Oct 5318(5847):113-6.  [Content Brief]

  [4]. Lapczynski A, et al. Fragrance material review on methyl salicylate. Food Chem Toxicol. 200745 Suppl 1:S428-52.  [Content Brief]

  [5]. Xin W, et al. Methyl salicylate lactoside inhibits inflammatory response of fibroblast-like synoviocytes and joint destruction in collagen-induced arthritis in mice. Br J Pharmacol. 2014 Jul171(14):3526-38.  [Content Brief]