2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Metopimazine

Metopimazine  (Synonyms: EXP999; RP9965)

製品番号: HY-116578 純度: 99.75%
COA 取扱説明書 Technical Support

Metopimazine (EXP999; RP9965) is a phenothiazine, orally available, selective dopamine D2 receptor antagonist that does not penetrate the blood-brain barrier. Metopimazine blocks dopamine D2 receptors in the chemoreceptor trigger zone and the periphery, thereby inhibiting nausea and vomiting. Metopimazine is indicated for chemotherapy-induced nausea and vomiting, and has low central side effects due to its poor brain penetration. The use of metopimazine in acute gastroenteritis may have potential risks.

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Metopimazine

Metopimazine 構造式

CAS 番号 : 14008-44-7

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 286 在庫あり
Solution
10 mM * 1 mL in DMSO USD 286 在庫あり
Solid
5 mg $260 在庫あり
10 mg $380 在庫あり
25 mg $800 在庫あり
50 mg $1280 在庫あり
100 mg $2100 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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Based on 3 publication(s) in Google Scholar

Other Forms of Metopimazine:

Metopimazine 関連抗体

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製品説明

Metopimazine (EXP999; RP9965) is a phenothiazine, orally available, selective dopamine D2 receptor antagonist that does not penetrate the blood-brain barrier. Metopimazine blocks dopamine D2 receptors in the chemoreceptor trigger zone and the periphery, thereby inhibiting nausea and vomiting. Metopimazine is indicated for chemotherapy-induced nausea and vomiting, and has low central side effects due to its poor brain penetration. The use of metopimazine in acute gastroenteritis may have potential risks[1][2][3].

IC50 & Target

D2 Receptor

 

体外実験

Metopimazine (10 μM; 60 min) has a brain permeability of 69.72% in an in vitro blood-brain barrier model of bovine brain capillary endothelial cells (BCEC) co-cultured with glial cells, while its metabolite metopimazine acid has a permeability of only 15.72%, which is significantly lower than that of the dopamine receptor antagonist control group[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Metopimazine 関連抗体
分子量

445.60

分子式

C22H27N3O3S2
CAS 番号
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N)C1CCN(CC1)CCCN2C3=C(SC4=CC=C(C=C24)S(=O)(C)=O)C=CC=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (112.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2442 mL 11.2208 mL 22.4417 mL
5 mM 0.4488 mL 2.2442 mL 4.4883 mL
10 mM 0.2244 mL 1.1221 mL 2.2442 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

V1

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濃度 （終了）

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体積 （終了）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2442 mL 11.2208 mL 22.4417 mL 56.1041 mL
5 mM 0.4488 mL 2.2442 mL 4.4883 mL 11.2208 mL
10 mM 0.2244 mL 1.1221 mL 2.2442 mL 5.6104 mL
15 mM 0.1496 mL 0.7481 mL 1.4961 mL 3.7403 mL
20 mM 0.1122 mL 0.5610 mL 1.1221 mL 2.8052 mL
25 mM 0.0898 mL 0.4488 mL 0.8977 mL 2.2442 mL
30 mM 0.0748 mL 0.3740 mL 0.7481 mL 1.8701 mL
40 mM 0.0561 mL 0.2805 mL 0.5610 mL 1.4026 mL
50 mM 0.0449 mL 0.2244 mL 0.4488 mL 1.1221 mL
60 mM 0.0374 mL 0.1870 mL 0.3740 mL 0.9351 mL
80 mM 0.0281 mL 0.1403 mL 0.2805 mL 0.7013 mL
100 mM 0.0224 mL 0.1122 mL 0.2244 mL 0.5610 mL
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Metopimazine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metopimazine14008-44-7EXP999 RP9965EXP 999EXP-999RP9965RP 9965RP-9965Dopamine Receptoranti-dopaminergic anti-emetics (ADA)phenothiazine derivativeemesisgastroenteritis (GE)Inhibitorinhibitorinhibit

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製品名:
Metopimazine
製品番号:
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