2. Immunology/Inflammation
  3. COX
  4. Metyrosine

Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.

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Metyrosine

Metyrosine Chemische Struktur

CAS. Nr. : 672-87-7

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Other Forms of Metyrosine:

Metyrosine Related Antibodies

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Beschreibung

Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2].

In Vitro

Metyrosine acts by inhibiting tyrosine hydroxylase, thus causing depletion of adrenal stores of catecholamines[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Metyrosine Related Antibodies
In Vivo

Metyrosine (50-200 mg/kg; i.p.) reduces carrageenan inflammation[1].
Metyrosine (50-200 mg/kg; i.p.) shows antiulcerative activity is 87.7%, 93.7% and 95.5% for 50, 100 and 200 mg/kg doses of metyrosine, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male albino Wistar rats (carrageenan-induced rat paw edema)[2]
Dosage: 50, 100 or 200 mg/kg
Administration: I.p.
Result: Reduced carrageenan inflammation at 50, 100 and 200 mg/kg doses (40%, 67% and 87%, respectively, at 4 h).
Klinische Studie
Molekulargewicht

195.22

Formel

C10H13NO3
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

C[C@](C(O)=O)(N)CC1=CC=C(O)C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Lösungsmittel & Löslichkeit
In Vitro: 

1 M HCl : 50 mg/mL (256.12 mM; Need ultrasonic)

H2O : 5 mg/mL (25.61 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.1225 mL 25.6124 mL 51.2248 mL
5 mM 1.0245 mL 5.1225 mL 10.2450 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Reinheit & Dokumentation

Purity: 99.64%

SDS (393 KB)

COA (246 KB) HNMR (130 KB) RP-HPLC (227 KB) LCMS (335 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / 1 M HCl 1 mM 5.1225 mL 25.6124 mL 51.2248 mL 128.0620 mL
5 mM 1.0245 mL 5.1225 mL 10.2450 mL 25.6124 mL
10 mM 0.5122 mL 2.5612 mL 5.1225 mL 12.8062 mL
15 mM 0.3415 mL 1.7075 mL 3.4150 mL 8.5375 mL
20 mM 0.2561 mL 1.2806 mL 2.5612 mL 6.4031 mL
25 mM 0.2049 mL 1.0245 mL 2.0490 mL 5.1225 mL
1 M HCl 30 mM 0.1707 mL 0.8537 mL 1.7075 mL 4.2687 mL
40 mM 0.1281 mL 0.6403 mL 1.2806 mL 3.2015 mL
50 mM 0.1024 mL 0.5122 mL 1.0245 mL 2.5612 mL
60 mM 0.0854 mL 0.4269 mL 0.8537 mL 2.1344 mL
80 mM 0.0640 mL 0.3202 mL 0.6403 mL 1.6008 mL
100 mM 0.0512 mL 0.2561 mL 0.5122 mL 1.2806 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Metyrosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metyrosine672-87-7COXCyclooxygenasegastricanti-ulcerativeCOX-2inflammationcatecholaminesynthesisbloodpressureInhibitorinhibitorinhibit

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