2. NF-κB Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Keap1-Nrf2 PPAR
  4. Monascin

Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor). Monascin is a Nrf2 activator and PPARγ agonist.

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Monascin

Monascin Chemical Structure

CAS No. : 21516-68-7

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Based on 2 publication(s) in Google Scholar

Other Forms of Monascin:

Monascin Related Antibodies

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Description

Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor). Monascin is a Nrf2 activator and PPARγ agonist[1][2].

Cellular Effect
Cell Line Type Value Description References
A-431 IC50
17.77 μM
Compound: 7
Antiproliferative activity against human A431 cells after 72 hrs
Antiproliferative activity against human A431 cells after 72 hrs
[PMID: 20655237]
IGROV-1 IC50
>30 μM
Compound: 7
Antiproliferative activity against human IGROV1 cells after 72 hrs
Antiproliferative activity against human IGROV1 cells after 72 hrs
[PMID: 20655237]
NCI-H460 IC50
>50 μM
Compound: 7
Antiproliferative activity against human NCI-H460 cells after 72 hrs
Antiproliferative activity against human NCI-H460 cells after 72 hrs
[PMID: 20655237]
In Vivo

Monascin (0.0025% in drinking water; mice) appears effective for the inhibition of UVB-initiated carcinogenesis on mouse skin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SENCAR mouse using a UVB irradiation as an initiator and TPA as a promoter[1].
Dosage: 0.0025% in drinking water.
Administration: Orally daily for 2 weeks in drinking water.
Result: Reduced the number of the papillomas.
Masse moléculaire

358.43

Formule

C21H26O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C([C@@H]1C(CCCCC)=O)O[C@]2(C)[C@]1([H])CC(C=C(/C=C/C)OC3)=C3C2=O
Structure Classification
Initial Source

Monascus pilosus
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvant et solubilité
In Vitro: 

DMSO : 50 mg/mL (139.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7899 mL 13.9497 mL 27.8995 mL
5 mM 0.5580 mL 2.7899 mL 5.5799 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Pureté et documentation

Purity: 99.79%

SDS (393 KB)

COA (253 KB) HNMR (298 KB) RP-HPLC (251 KB)

Instruction de manipulation (2659 KB)
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7899 mL 13.9497 mL 27.8995 mL 69.7486 mL
5 mM 0.5580 mL 2.7899 mL 5.5799 mL 13.9497 mL
10 mM 0.2790 mL 1.3950 mL 2.7899 mL 6.9749 mL
15 mM 0.1860 mL 0.9300 mL 1.8600 mL 4.6499 mL
20 mM 0.1395 mL 0.6975 mL 1.3950 mL 3.4874 mL
25 mM 0.1116 mL 0.5580 mL 1.1160 mL 2.7899 mL
30 mM 0.0930 mL 0.4650 mL 0.9300 mL 2.3250 mL
40 mM 0.0697 mL 0.3487 mL 0.6975 mL 1.7437 mL
50 mM 0.0558 mL 0.2790 mL 0.5580 mL 1.3950 mL
60 mM 0.0465 mL 0.2325 mL 0.4650 mL 1.1625 mL
80 mM 0.0349 mL 0.1744 mL 0.3487 mL 0.8719 mL
100 mM 0.0279 mL 0.1395 mL 0.2790 mL 0.6975 mL
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Monascin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Monascin21516-68-7Keap1-Nrf2PPARPeroxisome proliferator-activated receptorsPapillomasUVBInhibitorinhibitorinhibit

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