Muraglitazar (Synonyms: BMS-298585)

Name: Muraglitazar
Brand: MedChemExpress
SKU: HY-17445
Rating: 4.5 (0 reviews)

Cat. No.: HY-17445 Pureté: 98.38%: Fiche technique
COA

SDS
Instruction de manipulation
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Muraglitazar is a PPAR α/γ dual agonist for the research of type 2 diabetes and associated dyslipidemia. Muraglitazar shows potent activity in vitro at human PPARα (EC₅₀ = 320 nM) and PPARγ(EC₅₀ = 110 nM).

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Muraglitazar Chemical Structure

CAS No. : 331741-94-7

Size	Stock	Quantité
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtenir un devis	Estimated Time of Arrival: December 31
100 mg	Obtenir un devis
200 mg	Obtenir un devis

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Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform PPAR:

Voir toutes les isoformes

PPARα PPARβ/δ PPARγ PPAR PPARδ

Activité biologique
Pureté et documentation
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	0.035 μM Compound: I	Agonist activity at GAL4 tagged human PPARgamma ligand binding domain expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at GAL4 tagged human PPARgamma ligand binding domain expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 25686852]
HEK293	EC₅₀	0.04 μM Compound: 1, muraglitazar	Agonist activity at human PPARgamma expressed in HEK293 cells assessed as luciferase activity by GAL4 transactivation assay Agonist activity at human PPARgamma expressed in HEK293 cells assessed as luciferase activity by GAL4 transactivation assay	[PMID: 18511276]
HEK293	EC₅₀	1.41 μM Compound: 1, muraglitazar	Agonist activity at human PPARalpha expressed in HEK293 cells assessed as luciferase activity by GAL4 transactivation assay Agonist activity at human PPARalpha expressed in HEK293 cells assessed as luciferase activity by GAL4 transactivation assay	[PMID: 18511276]
HEK293	EC₅₀	1.41 μM Compound: I	Agonist activity at GAL4 tagged human PPARalpha ligand binding domain expressed in HEK293 cells by luciferase reporter gene assay Agonist activity at GAL4 tagged human PPARalpha ligand binding domain expressed in HEK293 cells by luciferase reporter gene assay	[PMID: 25686852]
HepG2	EC₅₀	0.09 μM Compound: muraglitazar	Agonist activity at human PPARgamma transactivation expressed in human HePG2 cells Agonist activity at human PPARgamma transactivation expressed in human HePG2 cells	[PMID: 18976908]
HepG2	EC₅₀	0.15 μM Compound: muraglitazar	Agonist activity at human PPARalpha transactivation expressed in human HePG2 cells Agonist activity at human PPARalpha transactivation expressed in human HePG2 cells	[PMID: 18976908]

Essai clinique

Masse moléculaire

516.54

Formule

C₂₉H₂₈N₂O₇

CAS No.

331741-94-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CN(C(OC1=CC=C(OC)C=C1)=O)CC2=CC=C(OCCC3=C(C)OC(C4=CC=CC=C4)=N3)C=C2

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 50 mg/mL (96.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9360 mL	9.6798 mL	19.3596 mL
5 mM	0.3872 mL	1.9360 mL	3.8719 mL
10 mM	0.1936 mL	0.9680 mL	1.9360 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureté et documentation

Purity: 98.38%

Select Batch:

Fiche technique (272 KB) SDS (393 KB)

COA (250 KB) HNMR (283 KB) LCMS (101 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Buse JB, Rubin CJ, Frederich R, et al. Muraglitazar, a dual (alpha/gamma) PPAR activator: a randomized, double-blind, placebo-controlled, 24-week monotherapy trial in adult patients with type 2 diabetes. Clin Ther. 2005;27(8):1181-1195. [Content Brief]

[2]. Cox SL. Muraglitazar: an agent for the treatment of type 2 diabetes and associated dyslipidemia. Drugs Today (Barc). 2005;41(9):579-587. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9360 mL	9.6798 mL	19.3596 mL	48.3990 mL
	5 mM	0.3872 mL	1.9360 mL	3.8719 mL	9.6798 mL
	10 mM	0.1936 mL	0.9680 mL	1.9360 mL	4.8399 mL
	15 mM	0.1291 mL	0.6453 mL	1.2906 mL	3.2266 mL
	20 mM	0.0968 mL	0.4840 mL	0.9680 mL	2.4199 mL
	25 mM	0.0774 mL	0.3872 mL	0.7744 mL	1.9360 mL
	30 mM	0.0645 mL	0.3227 mL	0.6453 mL	1.6133 mL
	40 mM	0.0484 mL	0.2420 mL	0.4840 mL	1.2100 mL
	50 mM	0.0387 mL	0.1936 mL	0.3872 mL	0.9680 mL
	60 mM	0.0323 mL	0.1613 mL	0.3227 mL	0.8066 mL
	80 mM	0.0242 mL	0.1210 mL	0.2420 mL	0.6050 mL

Muraglitazar Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Muraglitazar331741-94-7BMS-298585BMS298585BMS 298585PPARPeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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Muraglitazar (Synonyms: BMS-298585)

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Muraglitazar Related Antibodies

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform PPAR:

Activité biologique

Pureté et documentation

Références

Avis client

Calculateur de molarité

Calculateur de dilution

Complete Stock Solution Preparation Table

Muraglitazar Related Classifications

Keywords:

Vos produits récemment consultés:

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SAFETY DATA SHEET (SDS)

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