2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Muscarine

Muscarine ((+)-Muscarine) is an agonist of prototype mAChR. Muscarine is a toxin that can stimulate the parasympathetic nervous system.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Muscarine chloride) usually boasts enhanced water solubility and stability.

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Muscarine

Muscarine 構造式

CAS 番号 : 300-54-9

容量 在庫状況
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Other 在庫あり Forms of Muscarine:

Other Forms of Muscarine:

Muscarine 関連抗体

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mAChR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

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製品説明

Muscarine ((+)-Muscarine) is an agonist of prototype mAChR. Muscarine is a toxin that can stimulate the parasympathetic nervous system[1][2].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
130 nM
Compound: Muscarine
Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M3
Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M3
[PMID: 9622546]
CHO EC50
219 nM
Compound: Muscarine
Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M1
Inhibitory activity against stimulation of [3H]inositol monophosphate accumulation in [3H]inositol-labelled CHO transfected cells mediated by Muscarinic acetylcholine receptor M1
[PMID: 9622546]
CHO IC50
0.49 μM
Compound: Muscarine
Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP
Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the absence of GTP
[PMID: 9622546]
CHO IC50
3.9 μM
Compound: Muscarine
Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP
Inhibition of binding of 0.1 nM [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes of transfected CHO cells in the presence of 10 uM GTP
[PMID: 9622546]
CHO IC50
470 nM
Compound: Muscarine
Inhibitory activity against [3H]-cyclic AMP accumulation in CHO transfected cells mediated by Muscarinic acetylcholine receptor M4
Inhibitory activity against [3H]-cyclic AMP accumulation in CHO transfected cells mediated by Muscarinic acetylcholine receptor M4
[PMID: 9622546]
体外実験

Muscarine (100 µM) induces an intracellular calcium signal amplitude similar to the one triggered by 10 µM acetylcholine in brain miero vascular endothelial cells (BMVECs) and brain-derived Endothelial cells.3 (bEnd.3)[1].
Muscarine (1-30 μM; 2 min) produces a dose-dependent hyperpolarization in a sub-population of the nucleus raphe magnus (NRM) cells that contain 5-hydroxytryptamine (5-HT) on the NRM neurons with an EC50 value of 2.7 µM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Muscarine 関連抗体
分子量

174.26

分子式

C9H20NO2+
CAS 番号
SMILES

C[C@H]1[C@@H](C[C@H](O1)C[N+](C)(C)C)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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Muscarine Related Classifications

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The molarity calculator equation

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質量   濃度   体積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Muscarine300-54-9(+)-MuscarinemAChRMuscarinic acetylcholine receptorIntracellular calciumNRMNeuronInhibitorinhibitorinhibit

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製品名:
Muscarine
製品番号:
HY-121404
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