Nε-(Carboxyethyl)lysine 

Nε-(Carboxyethyl) lysine is an advanced glycation end product (AGE). Nε-(Carboxyethyl) lysine induces cross-linking between proteins, thereby affecting protein structure and function and causing protein denaturation. Nε-(Carboxyethyl) lysine binds to the RAGE receptor, affects cell signal transduction, and regulates processes such as inflammatory responses, cell proliferation, and apoptosis. Nε-(Carboxyethyl) lysine affects glutamate transporters, reduces glutamate uptake and S100β protein secretion, influences neurotransmission in the nervous system, and exhibits diabetes-related neurotoxicity^[1][2].

Nε-(Carboxyethyl) lysine binds to the RAGE receptor, affects cellular signal transduction, and regulates processes such as inflammatory responses, cell proliferation, and apoptosis^[1][2].
Nε-(Carboxyethyl) lysine affects glutamate transporters, reduces glutamate uptake and S100β protein secretion, impairs neurotransmission in the nervous system, and exhibits diabetes-related neurotoxicity^[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

218.25

C₉H₁₈N₂O₄

5746-03-2

Solid

White to off-white

N[C@@H](CCCCNC(C(O)=O)C)C(O)=O

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Ahmed MU, et al. N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins. Biochem J. 1997;324 ( Pt 2)(Pt 2):565-570.  [Content Brief]

  [2]. Hansen F, et al. Methylglyoxal and carboxyethyllysine reduce glutamate uptake and S100B secretion in the hippocampus independently of RAGE activation. Amino Acids. 2016;48(2):375-385.  [Content Brief]