5746-03-2
Chemical Structure
Nε-(Carboxyethyl)lysine
- CAS No.: 5746-03-2
- Formula:C9H18N2O4
- Molecular Weight:218.25
IUPAC Name: (2-methoxy-4-methylphenyl)glycine
InChIKey: XCYPSOHOIAZISD-MLWJPKLSSA-N
SMILES: N[C@@H](CCCCNC(C(O)=O)C)C(O)=O
Biological Activity: Nε-(Carboxyethyl) lysine is an advanced glycation end product (AGE). Nε-(Carboxyethyl) lysine induces cross-linking between proteins, thereby affecting protein structure and function and causing protein denaturation. Nε-(Carboxyethyl) lysine binds to the RAGE receptor, affects cell signal transduction, and regulates processes such as inflammatory responses, cell proliferation, and apoptosis. Nε-(Carboxyethyl) lysine affects glutamate transporters, reduces glutamate uptake and S100β protein secretion, influences neurotransmission in the nervous system, and exhibits diabetes-related neurotoxicity[1][2].
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Nε-(Carboxyethyl)lysine | 99.97% | Nε-(Carboxyethyl) lysine is an advanced glycation end product (AGE). Nε-(Carboxyethyl) lysine induces cross-linking between proteins, thereby affecting protein structure and function and causing protein denaturation. Nε-(Carboxyethyl) lysine binds to the RAGE receptor, affects cell signal transduction, and regulates processes such as inflammatory responses, cell proliferation, and apoptosis. Nε-(Carboxyethyl) lysine affects glutamate transporters, reduces glutamate uptake and S100β protein secretion, influences neurotransmission in the nervous system, and exhibits diabetes-related neurotoxicity. | ||||||||||||||||||||
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Nε-(Carboxyethyl)lysine-d4 | Nε-(Carboxyethyl)lysine-d4 is deuterium-labeled Nε-(Carboxyethyl)lysine. | |||||||||||||||||||||
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References
- [1]. Ahmed MU, et al. N-epsilon-(carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins. Biochem J. 1997;324 ( Pt 2)(Pt 2):565-570. [Content Brief]
- [2]. Hansen F, et al. Methylglyoxal and carboxyethyllysine reduce glutamate uptake and S100B secretion in the hippocampus independently of RAGE activation. Amino Acids. 2016;48(2):375-385. [Content Brief]
