Nε-(Carboxymethyl)-L-lysine
Based on 1 publication(s) in Google Scholar
Nε-(Carboxymethyl)-L-lysine (CML) is an orally active advanced glycation end product. Nε-(Carboxymethyl)-L-lysine upregulates the expression of PLK1 and CEP20, and induces the activation of RAGE and ERK/NFκB. Nε-(Carboxymethyl)-L-lysine drives centrosome amplification. Nε-(Carboxymethyl)-L-lysine induces malignant transformation of hepatocytes and promotes the development of hepatocellular carcinoma. Nε-(Carboxymethyl)-L-lysine induces epithelial-mesenchymal transition in osteosarcoma cells and enhances their migration and invasion properties.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 5746-04-3
- Formula: C8H16N2O4
- Molecular Weight:204.22
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Nε-(Carboxymethyl)-L-lysine
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Biological Activity
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PLK1 |
Nε-(Carboxymethyl)-L-lysine (25 μg/mL; 1-3 months) induces time-dependent centrosome amplification in THLE2 and THLE3 human hepatocytes, with 8-10-fold higher CA frequencies after 3 months of treatment[1].
Nε-(Carboxymethyl)-L-lysine (25 μg/mL; 1-3 months) upregulates PLK1 and CEP20 expression in THLE2 and THLE3 human hepatocytes, which are critical mediators of CML-driven centrosome amplification[1].
Nε-(Carboxymethyl)-L-lysine (25-50 μM; 6 days) significantly enhances the invasion ability of MG63 and U2OS human osteosarcoma cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 5746-04-3
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Appearance Solid
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Molecular Weight 204.22
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Formula C8H16N2O4
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Color White to off-white
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SMILES
C(CCNCC(=O)O)C[C@@H](C(=O)O)N
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Synonyms
CML; N6-(Carboxymethyl)-L-lysine; Nε-(1-Carboxymethyl)-L-lysine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Agric Food Chem
Nε-Carboxymethyl-Lysine Drives Centrosome Amplification and Hepatocarcinogenesis via Pathological Dysregulation of the PLK1-CEP20-CCDC116 Axis. [Abstract]2025 Dec 31;73(52):33215-33230. PMID: 41401801
Solvent & Solubility
H2O : 35 mg/mL (171.38 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Hu HM, et al. Nε-Carboxymethyl-Lysine Drives Centrosome Amplification and Hepatocarcinogenesis via Pathological Dysregulation of the PLK1-CEP20-CCDC116 Axis. J Agric Food Chem. 2025;73(52):33215-33230. [Content Brief]
[2]. Chang TY, et al. Nε-(1-Carboxymethyl)-L-lysine/RAGE Signaling Drives Metastasis and Cancer Stemness through ERK/NFκB axis in Osteosarcoma. Int J Biol Sci. 2024 Jan 12;20(3):880-896. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.8967 mL | 24.4834 mL | 48.9668 mL | 122.4170 mL |
| 5 mM | 0.9793 mL | 4.8967 mL | 9.7934 mL | 24.4834 mL | |
| 10 mM | 0.4897 mL | 2.4483 mL | 4.8967 mL | 12.2417 mL | |
| 15 mM | 0.3264 mL | 1.6322 mL | 3.2645 mL | 8.1611 mL | |
| 20 mM | 0.2448 mL | 1.2242 mL | 2.4483 mL | 6.1209 mL | |
| 25 mM | 0.1959 mL | 0.9793 mL | 1.9587 mL | 4.8967 mL | |
| 30 mM | 0.1632 mL | 0.8161 mL | 1.6322 mL | 4.0806 mL | |
| 40 mM | 0.1224 mL | 0.6121 mL | 1.2242 mL | 3.0604 mL | |
| 50 mM | 0.0979 mL | 0.4897 mL | 0.9793 mL | 2.4483 mL | |
| 60 mM | 0.0816 mL | 0.4081 mL | 0.8161 mL | 2.0403 mL | |
| 80 mM | 0.0612 mL | 0.3060 mL | 0.6121 mL | 1.5302 mL | |
| 100 mM | 0.0490 mL | 0.2448 mL | 0.4897 mL | 1.2242 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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