1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Fructosyl-lysine

Fructosyl-lysine (Synonyms: Fructoselysine)

Cat. No.: HY-129380
Handling Instructions

Fructosyl-lysine (Fructoselysine) is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection.

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Fructosyl-lysine Chemical Structure

Fructosyl-lysine Chemical Structure

CAS No. : 21291-40-7

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Description

Fructosyl-lysine (Fructoselysine) is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection[1].

IC50 & Target

IC50: precursor to glucosepane[2]

In Vitro

Fructosyl-lysine (5 mM; 0.5 hours) catalyzes the ATP-dependent conversion of [14C]fructoselysine to anionic products suggesting the existence of a fructoselysine-kinase activity in E .coli extracts[2].
Fructosyl-lysine (100 μM; 1 hour) contains a carbohydrate moiety and appears to be phosphorylated, it can be converted to glucose 6-phosphate in bacterial extracts in E .coli extracts[2].
Fructosyl-lysine (25 mM; 25 hours) lets E. coli growth at a rate of about one-third of that observed with glucose as a carbon source. Lysine itself does not support growth in the absence of other carbon source and does not affect the growth observed with glucose[2].

In Vivo

Fructosyl-lysine and AGE residues is increased markedly in glomeruli, retina, sciatic nerve, and plasma protein in diabetic rats[1].

Molecular Weight

308.33

Formula

C₁₂H₂₄N₂O₇

CAS No.

21291-40-7

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Fructosyl-lysineFructoselysineEndogenous MetaboliteneuropathyretinopathydiabeticAGEglomeruliretinasciaticnerveamadori glycationInhibitorinhibitorinhibit

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Fructosyl-lysine
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