Fructosyl-lysine dihydrochloride
Based on 1 publication(s) in Google Scholar
Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 96192-35-7
- Formula: C12H26Cl2N2O7
- Molecular Weight:381.25
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Fructosyl-lysine dihydrochloride
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
IC50: precursor to glucosepane[2]
Fructosyl-lysine dihydrochloride (5 mM; 0.5 hours) catalyzes the ATP-dependent conversion of [14C]fructoselysine to anionic products suggesting the existence of a fructoselysine-kinase activity in E .coli extracts[2].Fructosyl-lysine dihydrochloride (100 μM; 1 hour) contains a carbohydrate moiety and appears to be phosphorylated, it can be converted to glucose 6-phosphate in bacterial extracts in E .coli extracts[2].Fructosyl-lysine dihydrochloride (25 mM; 25 hours) lets E. coli growth at a rate of about one-third of that observed with glucose as a carbon source. Lysine itself does not support growth in the absence of other carbon source and does not affect the growth observed with glucose[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 96192-35-7
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Appearance Solid
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Molecular Weight 381.25
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Formula C12H26Cl2N2O7
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Color Brown to black
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SMILES
N[C@H](C(O)=O)CCCCNCC([C@@H](O)[C@H](O)[C@H](O)CO)=O.[H]Cl.[H]Cl
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Synonyms
Fructoselysine dihydrochloride
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Mol Med Rep
Causal association between metabolites and upper gastrointestinal tumors: A Mendelian randomization study. [Abstract]2024 Dec;30(6):212. PMID: 39370813
Solvent & Solubility
H2O : 40 mg/mL (104.92 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Rabbani N, et al. Hidden complexities in the measurement of fructosyl-lysine and advanced glycation end products for risk prediction of vascular complications of diabetes. Diabetes. 2015 Jan;64(1):9-11. [Content Brief]
[2]. Karachalias N, et al. Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats. Biochem Soc Trans. 2003 Dec;31(Pt 6):1423-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.6230 mL | 13.1148 mL | 26.2295 mL | 65.5738 mL |
| 5 mM | 0.5246 mL | 2.6230 mL | 5.2459 mL | 13.1148 mL | |
| 10 mM | 0.2623 mL | 1.3115 mL | 2.6230 mL | 6.5574 mL | |
| 15 mM | 0.1749 mL | 0.8743 mL | 1.7486 mL | 4.3716 mL | |
| 20 mM | 0.1311 mL | 0.6557 mL | 1.3115 mL | 3.2787 mL | |
| 25 mM | 0.1049 mL | 0.5246 mL | 1.0492 mL | 2.6230 mL | |
| 30 mM | 0.0874 mL | 0.4372 mL | 0.8743 mL | 2.1858 mL | |
| 40 mM | 0.0656 mL | 0.3279 mL | 0.6557 mL | 1.6393 mL | |
| 50 mM | 0.0525 mL | 0.2623 mL | 0.5246 mL | 1.3115 mL | |
| 60 mM | 0.0437 mL | 0.2186 mL | 0.4372 mL | 1.0929 mL | |
| 80 mM | 0.0328 mL | 0.1639 mL | 0.3279 mL | 0.8197 mL | |
| 100 mM | 0.0262 mL | 0.1311 mL | 0.2623 mL | 0.6557 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Fructosyl-lysine dihydrochloride Related Classifications
HY-129380A Related Classifications
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