1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Fructosyl-lysine dihydrochloride

Fructosyl-lysine dihydrochloride (Synonyms: Fructoselysine dihydrochloride)

Cat. No.: HY-129380A Purity: >95.0%
Handling Instructions

Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection.

For research use only. We do not sell to patients.

Fructosyl-lysine dihydrochloride Chemical Structure

Fructosyl-lysine dihydrochloride Chemical Structure

CAS No. : 96192-35-7

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Based on 1 publication(s) in Google Scholar

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Description

Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection[1].

IC50 & Target

IC50: precursor to glucosepane[2]

In Vitro

Fructosyl-lysine dihydrochloride (5 mM; 0.5 hours) catalyzes the ATP-dependent conversion of [14C]fructoselysine to anionic products suggesting the existence of a fructoselysine-kinase activity in E .coli extracts[2].
Fructosyl-lysine dihydrochloride (100 μM; 1 hour) contains a carbohydrate moiety and appears to be phosphorylated, it can be converted to glucose 6-phosphate in bacterial extracts in E .coli extracts[2].
Fructosyl-lysine dihydrochloride (25 mM; 25 hours) lets E. coli growth at a rate of about one-third of that observed with glucose as a carbon source. Lysine itself does not support growth in the absence of other carbon source and does not affect the growth observed with glucose[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fructosyl-lysine dihydrochloride and AGE residues is increased markedly in glomeruli, retina, sciatic nerve, and plasma protein in diabetic rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

381.25

Formula

C₁₂H₂₆Cl₂N₂O₇

CAS No.

96192-35-7

SMILES

N[[email protected]](C(O)=O)CCCCNCC([[email protected]@H](O)[[email protected]](O)[[email protected]](O)CO)=O.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

References

Purity: >95.0%

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Keywords:

Fructosyl-lysineFructoselysineEndogenous MetaboliteneuropathyretinopathydiabeticAGEglomeruliretinasciaticnerveamadori glycationInhibitorinhibitorinhibit

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Product Name:
Fructosyl-lysine dihydrochloride
Cat. No.:
HY-129380A
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