2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Fructosyl-lysine dihydrochloride

Fructosyl-lysine dihydrochloride  (Synonyms: Fructoselysine dihydrochloride)

Cat. No.: HY-129380A Purity: ≥95.0%
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Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection.

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Fructosyl-lysine dihydrochloride Chemical Structure

Fructosyl-lysine dihydrochloride Chemical Structure

CAS No. : 96192-35-7

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Based on 1 publication(s) in Google Scholar

Other Forms of Fructosyl-lysine dihydrochloride:

Fructosyl-lysine dihydrochloride Related Antibodies

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Description

Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection[1].

IC50 & Target

IC50: precursor to glucosepane[2]
In Vitro

Fructosyl-lysine dihydrochloride (5 mM; 0.5 hours) catalyzes the ATP-dependent conversion of [14C]fructoselysine to anionic products suggesting the existence of a fructoselysine-kinase activity in E .coli extracts[2].
Fructosyl-lysine dihydrochloride (100 μM; 1 hour) contains a carbohydrate moiety and appears to be phosphorylated, it can be converted to glucose 6-phosphate in bacterial extracts in E .coli extracts[2].
Fructosyl-lysine dihydrochloride (25 mM; 25 hours) lets E. coli growth at a rate of about one-third of that observed with glucose as a carbon source. Lysine itself does not support growth in the absence of other carbon source and does not affect the growth observed with glucose[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fructosyl-lysine dihydrochloride Related Antibodies
In Vivo

Fructosyl-lysine dihydrochloride and AGE residues is increased markedly in glomeruli, retina, sciatic nerve, and plasma protein in diabetic rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

381.25

Formula

C12H26Cl2N2O7
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

N[C@H](C(O)=O)CCCCNCC([C@@H](O)[C@H](O)[C@H](O)CO)=O.[H]Cl.[H]Cl
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 40 mg/mL (104.92 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6230 mL 13.1148 mL 26.2295 mL
5 mM 0.5246 mL 2.6230 mL 5.2459 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥95.0%

COA (245 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.6230 mL 13.1148 mL 26.2295 mL 65.5738 mL
5 mM 0.5246 mL 2.6230 mL 5.2459 mL 13.1148 mL
10 mM 0.2623 mL 1.3115 mL 2.6230 mL 6.5574 mL
15 mM 0.1749 mL 0.8743 mL 1.7486 mL 4.3716 mL
20 mM 0.1311 mL 0.6557 mL 1.3115 mL 3.2787 mL
25 mM 0.1049 mL 0.5246 mL 1.0492 mL 2.6230 mL
30 mM 0.0874 mL 0.4372 mL 0.8743 mL 2.1858 mL
40 mM 0.0656 mL 0.3279 mL 0.6557 mL 1.6393 mL
50 mM 0.0525 mL 0.2623 mL 0.5246 mL 1.3115 mL
60 mM 0.0437 mL 0.2186 mL 0.4372 mL 1.0929 mL
80 mM 0.0328 mL 0.1639 mL 0.3279 mL 0.8197 mL
100 mM 0.0262 mL 0.1311 mL 0.2623 mL 0.6557 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Fructosyl-lysine dihydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fructosyl-lysine96192-35-7FructoselysineEndogenous MetaboliteneuropathyretinopathydiabeticAGEglomeruliretinasciaticnerveamadori glycationInhibitorinhibitorinhibit

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