2. Metabolic Enzyme/Protease
  3. Drug Metabolite Endogenous Metabolite
  4. NAPQI

NAPQI  (Synonyms: N-アセチルベンゾキノンイミン)

製品番号: HY-W017464 純度: 98.0%
COA 取扱説明書 Technical Support

NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver.

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NAPQI

NAPQI 構造式

CAS 番号 : 50700-49-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 935 在庫あり
Solution
10 mM * 1 mL in DMSO USD 935 在庫あり
Solid
1 mg $290 在庫あり
5 mg $850 在庫あり
10 mg $1250 在庫あり
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100 mg   お問い合わせ  

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NAPQI 関連抗体

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Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

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Human Endogenous Metabolite Microbial Metabolite

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  • 純度とドキュメンテーション

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製品説明

NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver[1][2].

IC50 & Target

Human Endogenous Metabolite

 

体外実験

NAPQI (25-400 μM, 30 min) inhibits the synthesis of glutathione synthase (GS)[3].
NAPQI (0.15 mg/mL, 24-48 h) is toxic to auditory cell HEI-OC1 through oxidation and endoplasmic reticulum stress-dependent pathways[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NAPQI 関連抗体

Cell Viability Assay[4]

Cell Line: HEI-OC1
Concentration: 0.15 mg/mL
Incubation Time: 24, 48 h
Result: Decreased viability of HEI-OC1 cells at 24 and 48 h.
分子量

149.15

分子式

C8H7NO2
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(/N=C1C=CC(C=C\1)=O)=O
Structure Classification
Initial Source
輸送条件

Shipping with dry ice.
保管条件

-80°C, protect from light, stored under nitrogen
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (670.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.7047 mL 33.5233 mL 67.0466 mL
5 mM 1.3409 mL 6.7047 mL 13.4093 mL
10 mM 0.6705 mL 3.3523 mL 6.7047 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.33%

COA (247 KB) HNMR (137 KB) RP-HPLC (168 KB) LCMS (224 KB) Elemental Analysis Report (106 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.7047 mL 33.5233 mL 67.0466 mL 167.6165 mL
5 mM 1.3409 mL 6.7047 mL 13.4093 mL 33.5233 mL
10 mM 0.6705 mL 3.3523 mL 6.7047 mL 16.7617 mL
15 mM 0.4470 mL 2.2349 mL 4.4698 mL 11.1744 mL
20 mM 0.3352 mL 1.6762 mL 3.3523 mL 8.3808 mL
25 mM 0.2682 mL 1.3409 mL 2.6819 mL 6.7047 mL
30 mM 0.2235 mL 1.1174 mL 2.2349 mL 5.5872 mL
40 mM 0.1676 mL 0.8381 mL 1.6762 mL 4.1904 mL
50 mM 0.1341 mL 0.6705 mL 1.3409 mL 3.3523 mL
60 mM 0.1117 mL 0.5587 mL 1.1174 mL 2.7936 mL
80 mM 0.0838 mL 0.4190 mL 0.8381 mL 2.0952 mL
100 mM 0.0670 mL 0.3352 mL 0.6705 mL 1.6762 mL
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NAPQI Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NAPQI50700-49-7N-Acetyl-4-benzoquinone ImineDrug MetaboliteEndogenous Metabolitetoxic metabolitevitamin K cyclehepatotoxicityInhibitorinhibitorinhibit

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製品名:
NAPQI
製品番号:
HY-W017464
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