2. Protein Tyrosine Kinase/RTK
  3. PDGFR VEGFR FGFR
  4. Nintedanib-d3

Nintedanib-d3 is the deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

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Nintedanib-d<sub>3</sub>

Nintedanib-d3 Chemical Structure

CAS No. : 1624587-84-3

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1 mg Obtenir un devis 2-4 weeks 2-4 weeks 2-4 weeks 2-4 weeks
5 mg   Obtenir un devis  
10 mg   Obtenir un devis  
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Other Forms of Nintedanib-d3:

Nintedanib-d3 Related Antibodies

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PDGFR PDGFRβ PDGFRα

Voir tous les produits spécifiques à Isoform VEGFR:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Description

Nintedanib-d3 is the deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nintedanib-d3 Related Antibodies
Masse moléculaire

542.64

Formule

C31H30D3N5O4
CAS No.
Unlabeled CAS
Appearance

Solid

SMILES

O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N(C)C(CN4CCN(C([2H])([2H])[2H])CC4)=O)C=C3)/C5=CC=CC=C5)OC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvant et solubilité
In Vitro: 

DMSO : 100 mg/mL (184.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8428 mL 9.2142 mL 18.4284 mL
5 mM 0.3686 mL 1.8428 mL 3.6857 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Pureté et documentation
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8428 mL 9.2142 mL 18.4284 mL 46.0711 mL
5 mM 0.3686 mL 1.8428 mL 3.6857 mL 9.2142 mL
10 mM 0.1843 mL 0.9214 mL 1.8428 mL 4.6071 mL
15 mM 0.1229 mL 0.6143 mL 1.2286 mL 3.0714 mL
20 mM 0.0921 mL 0.4607 mL 0.9214 mL 2.3036 mL
25 mM 0.0737 mL 0.3686 mL 0.7371 mL 1.8428 mL
30 mM 0.0614 mL 0.3071 mL 0.6143 mL 1.5357 mL
40 mM 0.0461 mL 0.2304 mL 0.4607 mL 1.1518 mL
50 mM 0.0369 mL 0.1843 mL 0.3686 mL 0.9214 mL
60 mM 0.0307 mL 0.1536 mL 0.3071 mL 0.7679 mL
80 mM 0.0230 mL 0.1152 mL 0.2304 mL 0.5759 mL
100 mM 0.0184 mL 0.0921 mL 0.1843 mL 0.4607 mL
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Nintedanib-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nintedanib-d31624587-84-3BIBF 1120-d3PDGFRVEGFRFGFRPlatelet-derived growth factor receptorVascular endothelial growth factor receptorFibroblast growth factor receptorInhibitorinhibitorinhibit

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