2. Cell Cycle/DNA Damage Cytoskeleton
  3. Kinesin
  4. NSC-80141

NSC-80141 is a Kinesin-5 inhibitor. NSC-80141 exerts selective inhibitory activity against human kinesin-5 (HsEg5) (IC50: 9.4 μM), while shows weak inhibitory activity against Plasmodium kinesin-5 (PvEg5) (IC50: 27.3 μM). NSC-80141 serves as a tool compound for distinguishing human and Plasmodium homologous proteins.

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NSC-80141

NSC-80141 화학구조

CAS No. : 97027-56-0

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NSC-80141 Related Antibodies

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제품 설명

NSC-80141 is a Kinesin-5 inhibitor. NSC-80141 exerts selective inhibitory activity against human kinesin-5 (HsEg5) (IC50: 9.4 μM), while shows weak inhibitory activity against Plasmodium kinesin-5 (PvEg5) (IC50: 27.3 μM). NSC-80141 serves as a tool compound for distinguishing human and Plasmodium homologous proteins[1].

IC50 & Target[1]

Kinesin-5

 

In Vitro

NSC-80141 potently inhibits the basal ATPase activity and microtubule-stimulated ATPase activity of human kinesin-5 (HsEg5) and *Plasmodium vivax* kinesin-5 (PvEg5) (the IC50 value for basal HsEg5 activity is 9.4 μM, and that for basal PvEg5 activity is 27.3 μM; the IC50 value for microtubule-stimulated HsEg5 is 99 nM, and that for microtubule-stimulated PvEg5 is 769 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NSC-80141 Related Antibodies
분자량

250.12

화학식

C13H9Cl2N
CAS No.
SMILES

ClC=1C=C2C=3C=CC(N)=CC3CC2=CC1Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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NSC-80141 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC-8014197027-56-0NSC80141NSC 80141Kinesinmicrotubule-stimulated ATPase activityhuman Kinesin-5HsEg5PvEg5ATPase activityPlasmodium vivax Kinesin-5Inhibitorinhibitorinhibit

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상품명:
NSC-80141
Cat. No.:
HY-129302
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