2. 疾患モデリングル製品 Metabolic Enzyme/Protease Apoptosis
  3. Nervous System Disease Models Phosphatase Apoptosis
  4. Alzheimer's Disease Models
  5. Okadaic acid

オカダ酸  (Synonyms: Okadaic acid)

製品番号: HY-N6785 純度: 98.0%
COA 取扱説明書 Technical Support

Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation.

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CAS 番号 : 78111-17-8

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25 μg (124.2 μM * 250 μL in Ethanol) USD 230 在庫あり

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カスタマーレビュー

Based on 23 publication(s) in Google Scholar

Other Forms of Okadaic acid:

オカダ酸 関連抗体

Top Publications Citing Use of Products

    Okadaic acid purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 2;13(1):3.  [Abstract]

    Western blots of p-PP2Ac, PP2Ac, p-RIPK2, and RIPK2 in mouse chondrocytes transfected with Mysm1with or without Okadaic Acid (10 μM) treatment.

    Okadaic acid purchased from MedChemExpress. Usage Cited in: Bone Res. 2025 Jan 2;13(1):3.  [Abstract]

    Immunoprecipitation assay showing RIPK2 ubiquitination after Okadaic Acid(10 μM) treatment.

    Okadaic acid purchased from MedChemExpress. Usage Cited in: Biomaterials. 2024 Aug 6:312:122749.  [Abstract]

    Okadaic acid (30 nM; 24 h). Flow cytometry analysis of intracellular ROS in PC12 cells after different treatments.

    Okadaic acid purchased from MedChemExpress. Usage Cited in: Biomaterials. 2024 Aug 6:312:122749.  [Abstract]

    Okadaic acid (30 nM; 24 h). Live/dead fluorescence images of PC12 cells after different treatments.

    Okadaic acid purchased from MedChemExpress. Usage Cited in: Biomaterials. 2024 Aug 6:312:122749.  [Abstract]

    Okadaic acid (100 μM; 130 nL). Immunofluorescence staining of CD86− and Iba-1 positive cells in the cortex of mice subjected to different treatments.

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    製品説明

    Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation[1][2].

    IC50 & Target[1]

    PP1

    15-50 nM (IC50)

    PP2A

    0.1-0.3 nM (IC50)

    PP3

    3.7-4 nM (IC50)

    PP4

    0.1 nM (IC50)

    PP5

    3.5 nM (IC50)

    PP2B

    ~4000 nM (IC50)

    PP7

    ＞1000 nM (IC50)

    Cellular Effect
    Cell Line Type Value Description References
    HCT-116 IC50
    0.67 μM
    Compound: OA
    Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay
    Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay
    		[PMID: 28383915]
    HepG2 IC50
    0.54 μM
    Compound: OA
    Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
    Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
    		[PMID: 28383915]
    L1210 IC50
    5 ng/mL
    Compound: 3
    Cytotoxicity against mouse L1210 cells
    Cytotoxicity against mouse L1210 cells
    		[PMID: 7623052]
    N2a IC50
    0.85 μM
    Compound: OA
    Cytotoxicity against mouse Neuro2a cells after 24 hrs by MTT assay
    Cytotoxicity against mouse Neuro2a cells after 24 hrs by MTT assay
    		[PMID: 28383915]
    P388 EC50
    87 nM
    Compound: OA
    Blockade of okadaic acid-induced cytotoxicity in mouse P388 cells after 2 days by WST-8 assay in presence of Halichondria okadai recombinant OABP 2.3
    Blockade of okadaic acid-induced cytotoxicity in mouse P388 cells after 2 days by WST-8 assay in presence of Halichondria okadai recombinant OABP 2.3
    		[PMID: 20863709]
    P388 EC50
    92 nM
    Compound: OA
    Blockade of okadaic acid-induced cytotoxicity in mouse P388 cells after 2 days by WST-8 assay in presence of Halichondria okadai recombinant OABP 2.1
    Blockade of okadaic acid-induced cytotoxicity in mouse P388 cells after 2 days by WST-8 assay in presence of Halichondria okadai recombinant OABP 2.1
    		[PMID: 20863709]
    体外実験

    Okadaic acid (0-100 nM; 24 h or 48 h) inhibits the proliferation of AGS, MNK-45, Caco 2 cells[3].
    Okadaic acid (10 nM; 8 hours) increases Drp1 phosphorylation and mitochondrial fission in rat cortical neurons[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    オカダ酸 関連抗体

    Cell Proliferation Assay[3]

    Cell Line: AGS, MNK-45 and Caco 2 cell lines
    Concentration: 0-100 nM
    Incubation Time: 24 h or 48 h
    Result: Inhibited the proliferation of AGS, MNK-45, Caco 2 cells.
    体内実験

    Note:
    Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

    Okadaic acid can be used to induce Alzheimer's disease models[6].

    Induction of Alzheimer's disease model[6]
    Background
    Okadaic acid is a Ser/Thr phosphatase enzyme inhibitor that causes Tau hyperphosphorylation and induces the intracellular aggregation of neurofibrillary tangles.
    Specific Modeling Methods
    Mice: Wistar • male •-250-300 g
    Administration: 100μg • icv • single dose
    Modeling Indicators
    Molecular changes: Induced increases in pTauser396 in the hippocampus.

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    805.00

    分子式

    C44H68O13
    CAS 番号
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    O[C@H](CC[C@@H](C[C@@](C)(O)C(O)=O)O1)[C@@]1(C=C(C)C2)O[C@]2([H])[C@H](C)/C=C/[C@@H]3O[C@@]4(O[C@]([C@@H]5O)([H])[C@@](O[C@@]([C@@H](O)C[C@@H]([C@@]6([H])O[C@@]7(CCCCO7)CC[C@H]6C)C)([H])C5=C)([H])CC4)CC3
    Structure Classification
    Initial Source

    bivalve mollusks
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    Solution, -20°C, 2 years
    純度とドキュメンテーション

    純度: 99.19%

    COA (248 KB) RP-HPLC (341 KB)

    取扱説明書 (2659 KB)
    参考文献
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    Okadaic acid Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Okadaic acid78111-17-8PhosphataseApoptosisHalichondriaserine/threonine-specificproteinphosphatasesPP1PP2APP3Inhibitorinhibitorinhibit

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    製品名:
    Okadaic acid
    製品番号:
    HY-N6785
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