ON1231320

Name: ON1231320
Brand: MedChemExpress
SKU: HY-100789
Rating: 5.0 (2 reviews)

Cat. No.: HY-100789 Purity: 99.90%: Data Sheet
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ON1231320 is a highly specific polo like kinase 2 (PLK2) inhibitor with an IC₅₀ of 0.31 μM. ON1231320 blocks tumor cell cycle progression in the G2/M phase in mitosis, causing apoptotic cell death. ON1231320, an arylsulfonyl pyrido-pyrimidinone, has antitumor activity.

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ON1231320 화학구조

CAS No. : 1312471-39-8

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

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고객리뷰

Based on 2 publication(s) in Google Scholar

Other Forms of ON1231320:

ON1231320 (Standard) 견적 받기

2 Publications Citing Use of MCE ON1231320

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Polo-like Kinase (PLK) Isoform Specific Products:

View All Isoforms

PLK1 PLK2 PLK3 PLK4

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target^[1]

PLK2

0.31 μM (IC₅₀)

PLK1

>10 μM (IC₅₀)

PLK3

>10 μM (IC₅₀)

PLK4

>10 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
5637	GI₅₀	0.125 3 Compound: 7ao; ON1231320	Growth inhibition of human 5637 cells after 72 hrs by trypan blue assay Growth inhibition of human 5637 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
5637	GI₅₀	0.125 3 Compound: 7ao; ON1231320	Growth inhibition of human 5637 cells after 72 hrs by trypan blue assay Growth inhibition of human 5637 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
5637	GI₅₀	0.125 3 Compound: 7ao; ON1231320	Growth inhibition of human 5637 cells after 72 hrs by trypan blue assay Growth inhibition of human 5637 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
A-431	GI₅₀	0.03 3 Compound: 7ao; ON1231320	Growth inhibition of human A431 cells after 72 hrs by trypan blue assay Growth inhibition of human A431 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
A-431	GI₅₀	0.03 3 Compound: 7ao; ON1231320	Growth inhibition of human A431 cells after 72 hrs by trypan blue assay Growth inhibition of human A431 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
A-431	GI₅₀	0.03 3 Compound: 7ao; ON1231320	Growth inhibition of human A431 cells after 72 hrs by trypan blue assay Growth inhibition of human A431 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
A549	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human A549 cells after 72 hrs by trypan blue assay Growth inhibition of human A549 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
A549	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human A549 cells after 72 hrs by trypan blue assay Growth inhibition of human A549 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
A549	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human A549 cells after 72 hrs by trypan blue assay Growth inhibition of human A549 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
ASPC1	GI₅₀	0.3 3 Compound: 7ao; ON1231320	Growth inhibition of human AsPC1 cells after 72 hrs by trypan blue assay Growth inhibition of human AsPC1 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
ASPC1	GI₅₀	0.3 3 Compound: 7ao; ON1231320	Growth inhibition of human AsPC1 cells after 72 hrs by trypan blue assay Growth inhibition of human AsPC1 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
ASPC1	GI₅₀	0.3 3 Compound: 7ao; ON1231320	Growth inhibition of human AsPC1 cells after 72 hrs by trypan blue assay Growth inhibition of human AsPC1 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
BT-474	GI₅₀	0.1 3 Compound: 7ao; ON1231320	Growth inhibition of human BT474 cells after 72 hrs by trypan blue assay Growth inhibition of human BT474 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Bel-7402	GI₅₀	0.05 3 Compound: 7ao; ON1231320	Growth inhibition of human Bel7402 cells after 72 hrs by trypan blue assay Growth inhibition of human Bel7402 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Bel-7402	GI₅₀	0.05 3 Compound: 7ao; ON1231320	Growth inhibition of human Bel7402 cells after 72 hrs by trypan blue assay Growth inhibition of human Bel7402 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
BT-474	GI₅₀	0.1 3 Compound: 7ao; ON1231320	Growth inhibition of human BT474 cells after 72 hrs by trypan blue assay Growth inhibition of human BT474 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
BT-549	GI₅₀	0.25 3 Compound: 7ao; ON1231320	Growth inhibition of human BT549 cells after 72 hrs by trypan blue assay Growth inhibition of human BT549 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
BT-474	GI₅₀	0.1 3 Compound: 7ao; ON1231320	Growth inhibition of human BT474 cells after 72 hrs by trypan blue assay Growth inhibition of human BT474 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
BXPC-3	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human BxPC3 cells after 72 hrs by trypan blue assay Growth inhibition of human BxPC3 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
BT-549	GI₅₀	0.25 3 Compound: 7ao; ON1231320	Growth inhibition of human BT549 cells after 72 hrs by trypan blue assay Growth inhibition of human BT549 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
BT-549	GI₅₀	0.25 3 Compound: 7ao; ON1231320	Growth inhibition of human BT549 cells after 72 hrs by trypan blue assay Growth inhibition of human BT549 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Bel-7402	GI₅₀	0.05 3 Compound: 7ao; ON1231320	Growth inhibition of human Bel7402 cells after 72 hrs by trypan blue assay Growth inhibition of human Bel7402 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
BXPC-3	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human BxPC3 cells after 72 hrs by trypan blue assay Growth inhibition of human BxPC3 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
BXPC-3	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human BxPC3 cells after 72 hrs by trypan blue assay Growth inhibition of human BxPC3 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
CAPAN-1	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human Capan1 cells after 72 hrs by trypan blue assay Growth inhibition of human Capan1 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
CAPAN-1	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human Capan1 cells after 72 hrs by trypan blue assay Growth inhibition of human Capan1 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
CAPAN-1	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human Capan1 cells after 72 hrs by trypan blue assay Growth inhibition of human Capan1 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
CCRF-CEM	GI₅₀	0.05 3 Compound: 7ao; ON1231320	Growth inhibition of human CEM cells after 72 hrs by trypan blue assay Growth inhibition of human CEM cells after 72 hrs by trypan blue assay	[PMID: 26762835]
CCRF-CEM	GI₅₀	0.05 3 Compound: 7ao; ON1231320	Growth inhibition of human CEM cells after 72 hrs by trypan blue assay Growth inhibition of human CEM cells after 72 hrs by trypan blue assay	[PMID: 26762835]
CCRF-CEM	GI₅₀	0.05 3 Compound: 7ao; ON1231320	Growth inhibition of human CEM cells after 72 hrs by trypan blue assay Growth inhibition of human CEM cells after 72 hrs by trypan blue assay	[PMID: 26762835]
COLO 205	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human COLO205 cells after 72 hrs by trypan blue assay Growth inhibition of human COLO205 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
COLO 205	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human COLO205 cells after 72 hrs by trypan blue assay Growth inhibition of human COLO205 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
COLO 205	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human COLO205 cells after 72 hrs by trypan blue assay Growth inhibition of human COLO205 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Daudi	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human Daudi cells after 72 hrs by trypan blue assay Growth inhibition of human Daudi cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Daudi	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human Daudi cells after 72 hrs by trypan blue assay Growth inhibition of human Daudi cells after 72 hrs by trypan blue assay	[PMID: 26762835]
DU-145	IC₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human DU145 cells after 72 hrs by trypan blue assay Growth inhibition of human DU145 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
DU-145	IC₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human DU145 cells after 72 hrs by trypan blue assay Growth inhibition of human DU145 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Daudi	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human Daudi cells after 72 hrs by trypan blue assay Growth inhibition of human Daudi cells after 72 hrs by trypan blue assay	[PMID: 26762835]
DU-145	IC₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human DU145 cells after 72 hrs by trypan blue assay Growth inhibition of human DU145 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Granta-519	GI₅₀	0.04 3 Compound: 7ao; ON1231320	Growth inhibition of human GRANTA-519 cells after 72 hrs by trypan blue assay Growth inhibition of human GRANTA-519 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Granta-519	GI₅₀	0.04 3 Compound: 7ao; ON1231320	Growth inhibition of human GRANTA-519 cells after 72 hrs by trypan blue assay Growth inhibition of human GRANTA-519 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Granta-519	GI₅₀	0.04 3 Compound: 7ao; ON1231320	Growth inhibition of human GRANTA-519 cells after 72 hrs by trypan blue assay Growth inhibition of human GRANTA-519 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
HCC1806	GI₅₀	0.1 3 Compound: 7ao; ON1231320	Growth inhibition of human HCC1806 cells after 72 hrs by trypan blue assay Growth inhibition of human HCC1806 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
HCC1806	GI₅₀	0.1 3 Compound: 7ao; ON1231320	Growth inhibition of human HCC1806 cells after 72 hrs by trypan blue assay Growth inhibition of human HCC1806 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
HCC1806	GI₅₀	0.1 3 Compound: 7ao; ON1231320	Growth inhibition of human HCC1806 cells after 72 hrs by trypan blue assay Growth inhibition of human HCC1806 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
HCT-116	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human HCT116 cells after 72 hrs by trypan blue assay Growth inhibition of human HCT116 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
HCT-116	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human HCT116 cells after 72 hrs by trypan blue assay Growth inhibition of human HCT116 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
HCT-116	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human HCT116 cells after 72 hrs by trypan blue assay Growth inhibition of human HCT116 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
HFL1	GI₅₀	> 2 3 Compound: 7ao; ON1231320	Growth inhibition of human HFL1 cells after 72 hrs by trypan blue assay Growth inhibition of human HFL1 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
HeLa	GI₅₀	0.05 3 Compound: 7ao; ON1231320	Growth inhibition of human HeLa cells after 72 hrs by trypan blue assay Growth inhibition of human HeLa cells after 72 hrs by trypan blue assay	[PMID: 26762835]
HeLa	GI₅₀	0.05 3 Compound: 7ao; ON1231320	Growth inhibition of human HeLa cells after 72 hrs by trypan blue assay Growth inhibition of human HeLa cells after 72 hrs by trypan blue assay	[PMID: 26762835]
HL-60	GI₅₀	0.125 3 Compound: 7ao; ON1231320	Growth inhibition of human HL60 cells after 72 hrs by trypan blue assay Growth inhibition of human HL60 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
HepG2	GI₅₀	0.5 3 Compound: 7ao; ON1231320	Growth inhibition of human HepG2 cells after 72 hrs by trypan blue assay Growth inhibition of human HepG2 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
HepG2	GI₅₀	0.5 3 Compound: 7ao; ON1231320	Growth inhibition of human HepG2 cells after 72 hrs by trypan blue assay Growth inhibition of human HepG2 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
HeLa	GI₅₀	0.05 3 Compound: 7ao; ON1231320	Growth inhibition of human HeLa cells after 72 hrs by trypan blue assay Growth inhibition of human HeLa cells after 72 hrs by trypan blue assay	[PMID: 26762835]
HFL1	GI₅₀	> 2 3 Compound: 7ao; ON1231320	Growth inhibition of human HFL1 cells after 72 hrs by trypan blue assay Growth inhibition of human HFL1 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
HFL1	GI₅₀	>2 3 Compound: 7ao; ON1231320	Growth inhibition of human HFL1 cells after 72 hrs by trypan blue assay Growth inhibition of human HFL1 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
HepG2	GI₅₀	0.5 3 Compound: 7ao; ON1231320	Growth inhibition of human HepG2 cells after 72 hrs by trypan blue assay Growth inhibition of human HepG2 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
HL-60	GI₅₀	0.125 3 Compound: 7ao; ON1231320	Growth inhibition of human HL60 cells after 72 hrs by trypan blue assay Growth inhibition of human HL60 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
HL-60	GI₅₀	0.125 3 Compound: 7ao; ON1231320	Growth inhibition of human HL60 cells after 72 hrs by trypan blue assay Growth inhibition of human HL60 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Jurkat	GI₅₀	0.025 3 Compound: 7ao; ON1231320	Growth inhibition of human Jurkat cells after 72 hrs by trypan blue assay Growth inhibition of human Jurkat cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Jurkat	GI₅₀	0.025 3 Compound: 7ao; ON1231320	Growth inhibition of human Jurkat cells after 72 hrs by trypan blue assay Growth inhibition of human Jurkat cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Jurkat	GI₅₀	0.025 3 Compound: 7ao; ON1231320	Growth inhibition of human Jurkat cells after 72 hrs by trypan blue assay Growth inhibition of human Jurkat cells after 72 hrs by trypan blue assay	[PMID: 26762835]
K562	IC₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human K562 cells after 72 hrs by trypan blue assay Growth inhibition of human K562 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
K562	IC₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human K562 cells after 72 hrs by trypan blue assay Growth inhibition of human K562 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
K562	IC₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human K562 cells after 72 hrs by trypan blue assay Growth inhibition of human K562 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
LNCaP	GI₅₀	0.04 3 Compound: 7ao; ON1231320	Growth inhibition of human LNCAP cells after 72 hrs by trypan blue assay Growth inhibition of human LNCAP cells after 72 hrs by trypan blue assay	[PMID: 26762835]
LNCaP	GI₅₀	0.04 3 Compound: 7ao; ON1231320	Growth inhibition of human LNCAP cells after 72 hrs by trypan blue assay Growth inhibition of human LNCAP cells after 72 hrs by trypan blue assay	[PMID: 26762835]
LNCaP	GI₅₀	0.04 3 Compound: 7ao; ON1231320	Growth inhibition of human LNCAP cells after 72 hrs by trypan blue assay Growth inhibition of human LNCAP cells after 72 hrs by trypan blue assay	[PMID: 26762835]
MCF7	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human MCF7 cells after 72 hrs by trypan blue assay Growth inhibition of human MCF7 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
MCF7	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human MCF7 cells after 72 hrs by trypan blue assay Growth inhibition of human MCF7 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
MCF7	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human MCF7 cells after 72 hrs by trypan blue assay Growth inhibition of human MCF7 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
MDA-MB-436	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human MDA-MB-436 cells after 72 hrs by trypan blue assay Growth inhibition of human MDA-MB-436 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
MDA-MB-436	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human MDA-MB-436 cells after 72 hrs by trypan blue assay Growth inhibition of human MDA-MB-436 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
MDA-MB-453	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human MDA-MB-453 cells after 72 hrs by trypan blue assay Growth inhibition of human MDA-MB-453 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
MDA-MB-436	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human MDA-MB-436 cells after 72 hrs by trypan blue assay Growth inhibition of human MDA-MB-436 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
MDA-MB-453	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human MDA-MB-453 cells after 72 hrs by trypan blue assay Growth inhibition of human MDA-MB-453 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
MIA PaCa-2	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human MIAPaCa2 cells after 72 hrs by trypan blue assay Growth inhibition of human MIAPaCa2 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
MIA PaCa-2	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human MIAPaCa2 cells after 72 hrs by trypan blue assay Growth inhibition of human MIAPaCa2 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
MDA-MB-453	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human MDA-MB-453 cells after 72 hrs by trypan blue assay Growth inhibition of human MDA-MB-453 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
NCI-H1650	GI₅₀	0.2 3 Compound: 7ao; ON1231320	Growth inhibition of human NCI-H1650 cells after 72 hrs by trypan blue assay Growth inhibition of human NCI-H1650 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
MIA PaCa-2	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human MIAPaCa2 cells after 72 hrs by trypan blue assay Growth inhibition of human MIAPaCa2 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
NCI-H1650	GI₅₀	0.2 3 Compound: 7ao; ON1231320	Growth inhibition of human NCI-H1650 cells after 72 hrs by trypan blue assay Growth inhibition of human NCI-H1650 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
NCI-H1734	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human NCI-H1734 cells after 72 hrs by trypan blue assay Growth inhibition of human NCI-H1734 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
NCI-H1650	GI₅₀	0.2 3 Compound: 7ao; ON1231320	Growth inhibition of human NCI-H1650 cells after 72 hrs by trypan blue assay Growth inhibition of human NCI-H1650 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
NCI-H1734	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human NCI-H1734 cells after 72 hrs by trypan blue assay Growth inhibition of human NCI-H1734 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
NCI-H1734	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human NCI-H1734 cells after 72 hrs by trypan blue assay Growth inhibition of human NCI-H1734 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
NCI-H1975	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human NCI-H1975 cells after 72 hrs by trypan blue assay Growth inhibition of human NCI-H1975 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
NCI-H1975	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human NCI-H1975 cells after 72 hrs by trypan blue assay Growth inhibition of human NCI-H1975 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
NCI-H23	GI₅₀	0.2 3 Compound: 7ao; ON1231320	Growth inhibition of human H23 cells after 72 hrs by trypan blue assay Growth inhibition of human H23 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
NCI-H1975	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human NCI-H1975 cells after 72 hrs by trypan blue assay Growth inhibition of human NCI-H1975 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
NCI-H23	GI₅₀	0.2 3 Compound: 7ao; ON1231320	Growth inhibition of human H23 cells after 72 hrs by trypan blue assay Growth inhibition of human H23 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
NCI-H292	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human NCI-H292 cells after 72 hrs by trypan blue assay Growth inhibition of human NCI-H292 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
NCI-H292	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human NCI-H292 cells after 72 hrs by trypan blue assay Growth inhibition of human NCI-H292 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
NCI-H23	GI₅₀	0.2 3 Compound: 7ao; ON1231320	Growth inhibition of human H23 cells after 72 hrs by trypan blue assay Growth inhibition of human H23 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
NCI-H292	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human NCI-H292 cells after 72 hrs by trypan blue assay Growth inhibition of human NCI-H292 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
NCI-H460	GI₅₀	0.1 3 Compound: 7ao; ON1231320	Growth inhibition of human H460 cells after 72 hrs by trypan blue assay Growth inhibition of human H460 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
NCI-H460	GI₅₀	0.1 3 Compound: 7ao; ON1231320	Growth inhibition of human H460 cells after 72 hrs by trypan blue assay Growth inhibition of human H460 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Panc1005	GI₅₀	0.4 3 Compound: 7ao; ON1231320	Growth inhibition of human Panc 10.05 cells after 72 hrs by trypan blue assay Growth inhibition of human Panc 10.05 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Panc1005	GI₅₀	0.4 3 Compound: 7ao; ON1231320	Growth inhibition of human Panc 10.05 cells after 72 hrs by trypan blue assay Growth inhibition of human Panc 10.05 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
NCI-H460	GI₅₀	0.1 3 Compound: 7ao; ON1231320	Growth inhibition of human H460 cells after 72 hrs by trypan blue assay Growth inhibition of human H460 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
PC-3	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human PC3 cells after 72 hrs by trypan blue assay Growth inhibition of human PC3 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
PC-3	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human PC3 cells after 72 hrs by trypan blue assay Growth inhibition of human PC3 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
PC-3	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human PC3 cells after 72 hrs by trypan blue assay Growth inhibition of human PC3 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
PLC-PRF-5	GI₅₀	0.75 3 Compound: 7ao; ON1231320	Growth inhibition of human PLC/PRF/5 cells after 72 hrs by trypan blue assay Growth inhibition of human PLC/PRF/5 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
PLC-PRF-5	GI₅₀	0.75 3 Compound: 7ao; ON1231320	Growth inhibition of human PLC/PRF/5 cells after 72 hrs by trypan blue assay Growth inhibition of human PLC/PRF/5 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
PLC-PRF-5	GI₅₀	0.75 3 Compound: 7ao; ON1231320	Growth inhibition of human PLC/PRF/5 cells after 72 hrs by trypan blue assay Growth inhibition of human PLC/PRF/5 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Raji	GI₅₀	0.05 3 Compound: 7ao; ON1231320	Growth inhibition of human Raji cells after 72 hrs by trypan blue assay Growth inhibition of human Raji cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Panc1005	GI₅₀	0.4 3 Compound: 7ao; ON1231320	Growth inhibition of human Panc 10.05 cells after 72 hrs by trypan blue assay Growth inhibition of human Panc 10.05 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Raji	GI₅₀	0.05 3 Compound: 7ao; ON1231320	Growth inhibition of human Raji cells after 72 hrs by trypan blue assay Growth inhibition of human Raji cells after 72 hrs by trypan blue assay	[PMID: 26762835]
RT-4	GI₅₀	0.5 3 Compound: 7ao; ON1231320	Growth inhibition of human RT4 cells after 72 hrs by trypan blue assay Growth inhibition of human RT4 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
RT-4	GI₅₀	0.5 3 Compound: 7ao; ON1231320	Growth inhibition of human RT4 cells after 72 hrs by trypan blue assay Growth inhibition of human RT4 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
RT-4	GI₅₀	0.5 3 Compound: 7ao; ON1231320	Growth inhibition of human RT4 cells after 72 hrs by trypan blue assay Growth inhibition of human RT4 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Raji	GI₅₀	0.05 3 Compound: 7ao; ON1231320	Growth inhibition of human Raji cells after 72 hrs by trypan blue assay Growth inhibition of human Raji cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SK-HEP1	GI₅₀	0.1 3 Compound: 7ao; ON1231320	Growth inhibition of human SKHEP1 cells after 72 hrs by trypan blue assay Growth inhibition of human SKHEP1 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SK-HEP1	GI₅₀	0.1 3 Compound: 7ao; ON1231320	Growth inhibition of human SKHEP1 cells after 72 hrs by trypan blue assay Growth inhibition of human SKHEP1 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SK-HEP1	GI₅₀	0.1 3 Compound: 7ao; ON1231320	Growth inhibition of human SKHEP1 cells after 72 hrs by trypan blue assay Growth inhibition of human SKHEP1 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SK-MEL-28	GI₅₀	0.2 3 Compound: 7ao; ON1231320	Growth inhibition of human SK-MEL-28 cells after 72 hrs by trypan blue assay Growth inhibition of human SK-MEL-28 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SK-MEL-28	GI₅₀	0.2 3 Compound: 7ao; ON1231320	Growth inhibition of human SK-MEL-28 cells after 72 hrs by trypan blue assay Growth inhibition of human SK-MEL-28 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SK-OV-3	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human SKOV3 cells after 72 hrs by trypan blue assay Growth inhibition of human SKOV3 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SK-MEL-28	GI₅₀	0.2 3 Compound: 7ao; ON1231320	Growth inhibition of human SK-MEL-28 cells after 72 hrs by trypan blue assay Growth inhibition of human SK-MEL-28 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SK-OV-3	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human SKOV3 cells after 72 hrs by trypan blue assay Growth inhibition of human SKOV3 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SNU-398	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human SNU398 cells after 72 hrs by trypan blue assay Growth inhibition of human SNU398 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SK-OV-3	GI₅₀	0.075 3 Compound: 7ao; ON1231320	Growth inhibition of human SKOV3 cells after 72 hrs by trypan blue assay Growth inhibition of human SKOV3 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SNU-398	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human SNU398 cells after 72 hrs by trypan blue assay Growth inhibition of human SNU398 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SNU-449	GI₅₀	0.4 3 Compound: 7ao; ON1231320	Growth inhibition of human SNU449 cells after 72 hrs by trypan blue assay Growth inhibition of human SNU449 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SNU-449	GI₅₀	0.4 3 Compound: 7ao; ON1231320	Growth inhibition of human SNU449 cells after 72 hrs by trypan blue assay Growth inhibition of human SNU449 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SNU-398	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human SNU398 cells after 72 hrs by trypan blue assay Growth inhibition of human SNU398 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SNU-449	GI₅₀	0.4 3 Compound: 7ao; ON1231320	Growth inhibition of human SNU449 cells after 72 hrs by trypan blue assay Growth inhibition of human SNU449 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SNU-475	GI₅₀	7.5 3 Compound: 7ao; ON1231320	Growth inhibition of human SNU475 cells after 72 hrs by trypan blue assay Growth inhibition of human SNU475 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SNU-475	GI₅₀	7.5 3 Compound: 7ao; ON1231320	Growth inhibition of human SNU475 cells after 72 hrs by trypan blue assay Growth inhibition of human SNU475 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SNU-475	GI₅₀	7.5 3 Compound: 7ao; ON1231320	Growth inhibition of human SNU475 cells after 72 hrs by trypan blue assay Growth inhibition of human SNU475 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SU.86.86	GI₅₀	0.4 3 Compound: 7ao; ON1231320	Growth inhibition of human SU8686 cells after 72 hrs by trypan blue assay Growth inhibition of human SU8686 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SU.86.86	GI₅₀	0.4 3 Compound: 7ao; ON1231320	Growth inhibition of human SU8686 cells after 72 hrs by trypan blue assay Growth inhibition of human SU8686 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SW780	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human SW780 cells after 72 hrs by trypan blue assay Growth inhibition of human SW780 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SW780	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human SW780 cells after 72 hrs by trypan blue assay Growth inhibition of human SW780 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SU.86.86	GI₅₀	0.4 3 Compound: 7ao; ON1231320	Growth inhibition of human SU8686 cells after 72 hrs by trypan blue assay Growth inhibition of human SU8686 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
SW780	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human SW780 cells after 72 hrs by trypan blue assay Growth inhibition of human SW780 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
T-24	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human T24 cells after 72 hrs by trypan blue assay Growth inhibition of human T24 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
T-24	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human T24 cells after 72 hrs by trypan blue assay Growth inhibition of human T24 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
T-24	GI₅₀	0.15 3 Compound: 7ao; ON1231320	Growth inhibition of human T24 cells after 72 hrs by trypan blue assay Growth inhibition of human T24 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
TCC-SUP	GI₅₀	0.25 3 Compound: 7ao; ON1231320	Growth inhibition of human TCCSUP cells after 72 hrs by trypan blue assay Growth inhibition of human TCCSUP cells after 72 hrs by trypan blue assay	[PMID: 26762835]
TCC-SUP	GI₅₀	0.25 3 Compound: 7ao; ON1231320	Growth inhibition of human TCCSUP cells after 72 hrs by trypan blue assay Growth inhibition of human TCCSUP cells after 72 hrs by trypan blue assay	[PMID: 26762835]
TCC-SUP	GI₅₀	0.25 3 Compound: 7ao; ON1231320	Growth inhibition of human TCCSUP cells after 72 hrs by trypan blue assay Growth inhibition of human TCCSUP cells after 72 hrs by trypan blue assay	[PMID: 26762835]
U2OS	GI₅₀	0.035 3 Compound: 7ao; ON1231320	Growth inhibition of human U2OS cells after 72 hrs by trypan blue assay Growth inhibition of human U2OS cells after 72 hrs by trypan blue assay	[PMID: 26762835]
U2OS	GI₅₀	0.035 3 Compound: 7ao; ON1231320	Growth inhibition of human U2OS cells after 72 hrs by trypan blue assay Growth inhibition of human U2OS cells after 72 hrs by trypan blue assay	[PMID: 26762835]
U-87MG ATCC	GI₅₀	0.02 3 Compound: 7ao; ON1231320	Growth inhibition of human U87 cells after 72 hrs by trypan blue assay Growth inhibition of human U87 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
U-87MG ATCC	GI₅₀	0.02 3 Compound: 7ao; ON1231320	Growth inhibition of human U87 cells after 72 hrs by trypan blue assay Growth inhibition of human U87 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
U-87MG ATCC	GI₅₀	0.02 3 Compound: 7ao; ON1231320	Growth inhibition of human U87 cells after 72 hrs by trypan blue assay Growth inhibition of human U87 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
U-937	GI₅₀	0.125 3 Compound: 7ao; ON1231320	Growth inhibition of human U937 cells after 72 hrs by trypan blue assay Growth inhibition of human U937 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
U-937	GI₅₀	0.125 3 Compound: 7ao; ON1231320	Growth inhibition of human U937 cells after 72 hrs by trypan blue assay Growth inhibition of human U937 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
U-937	GI₅₀	0.125 3 Compound: 7ao; ON1231320	Growth inhibition of human U937 cells after 72 hrs by trypan blue assay Growth inhibition of human U937 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
U2OS	GI₅₀	0.035 3 Compound: 7ao; ON1231320	Growth inhibition of human U2OS cells after 72 hrs by trypan blue assay Growth inhibition of human U2OS cells after 72 hrs by trypan blue assay	[PMID: 26762835]
UMUC3	GI₅₀	0.3 3 Compound: 7ao; ON1231320	Growth inhibition of human UM-UC-3 cells after 72 hrs by trypan blue assay Growth inhibition of human UM-UC-3 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
UMUC3	GI₅₀	0.3 3 Compound: 7ao; ON1231320	Growth inhibition of human UM-UC-3 cells after 72 hrs by trypan blue assay Growth inhibition of human UM-UC-3 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
WI-38	GI₅₀	>5 3 Compound: 7ao; ON1231320	Growth inhibition of human WI38 cells after 72 hrs by trypan blue assay Growth inhibition of human WI38 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
UMUC3	GI₅₀	0.3 3 Compound: 7ao; ON1231320	Growth inhibition of human UM-UC-3 cells after 72 hrs by trypan blue assay Growth inhibition of human UM-UC-3 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
WI-38	GI₅₀	> 5 3 Compound: 7ao; ON1231320	Growth inhibition of human WI38 cells after 72 hrs by trypan blue assay Growth inhibition of human WI38 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
WI-38	GI₅₀	> 5 3 Compound: 7ao; ON1231320	Growth inhibition of human WI38 cells after 72 hrs by trypan blue assay Growth inhibition of human WI38 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Z-138	GI₅₀	0.2 3 Compound: 7ao; ON1231320	Growth inhibition of human Z138 cells after 72 hrs by trypan blue assay Growth inhibition of human Z138 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Z-138	GI₅₀	0.2 3 Compound: 7ao; ON1231320	Growth inhibition of human Z138 cells after 72 hrs by trypan blue assay Growth inhibition of human Z138 cells after 72 hrs by trypan blue assay	[PMID: 26762835]
Z-138	GI₅₀	0.2 3 Compound: 7ao; ON1231320	Growth inhibition of human Z138 cells after 72 hrs by trypan blue assay Growth inhibition of human Z138 cells after 72 hrs by trypan blue assay	[PMID: 26762835]

In Vitro

ON1231320 (Compound 7ao) has no inhibitory activity against PLK1, PLK3 and PLK4 (all IC₅₀>10 μM)^[1].
ON1231320 (0-5 μM; 24 hours) activates programmed cell death in human tumor cells^[1].
ON1231320 inhibits cell proliferation in 16 tumor cell lines (DU145, MCF-7, BT474, SK-OV-3, MIA-PaCa-2, SK-MEL-28, A549, U87, COLO-205, HELA, H1975, RAJI, U205, K562, GRANTA-519; IC₅₀= 0.035-0.2 μM)^[1].
ON1231320 does not appreciably inhibit tubulin polymerization^[1]. ON1231320 does not affect normal human fibroblasts^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:	U2OS cells
Concentration:	0-5 µM
Incubation Time:	24 hours
Result:	Increased the activity of Caspases 3/7 in a dose-dependent manner. Induced apoptosis.

In Vivo

ON1231320 (Compound 7ao; 75 mg/kg; IP; alternate days (Q2D) for 20 days) results in significant inhibition of tumor growth^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-8 week old NCR nu/nu female mice with MDAMB-231 triple negative breast cancer cells^[1]
Dosage:	75 mg/kg
Administration:	IP; alternate days (Q2D) for 20 days
Result:	Resulted in significant inhibition of tumor growth (86.5%)

분자량

467.45

화학식

C₂₂H₁₅F₂N₅O₃S

CAS No.

1312471-39-8

Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C1C(S(=O)(C2=CC=C(F)C=C2F)=O)=CC3=CN=C(NC4=CC5=C(NC=C5)C=C4)N=C3N1C

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 50 mg/mL (106.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1393 mL	10.6963 mL	21.3927 mL
5 mM	0.4279 mL	2.1393 mL	4.2785 mL
10 mM	0.2139 mL	1.0696 mL	2.1393 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (5.35 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 99.90%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (248 KB) HNMR (266 KB) RP-HPLC (255 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. M V Ramana Reddy, et al. Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2). Bioorg Med Chem. 2016 Feb 15;24(4):521-44. [Content Brief]

[2]. Shashidhar S. Jatiani, et al. Abstract 643: Targeting cancer with a selective ATP-mimetic inhibitor of polo like kinase-2.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1393 mL	10.6963 mL	21.3927 mL	53.4817 mL
	5 mM	0.4279 mL	2.1393 mL	4.2785 mL	10.6963 mL
	10 mM	0.2139 mL	1.0696 mL	2.1393 mL	5.3482 mL
	15 mM	0.1426 mL	0.7131 mL	1.4262 mL	3.5654 mL
	20 mM	0.1070 mL	0.5348 mL	1.0696 mL	2.6741 mL
	25 mM	0.0856 mL	0.4279 mL	0.8557 mL	2.1393 mL
	30 mM	0.0713 mL	0.3565 mL	0.7131 mL	1.7827 mL
	40 mM	0.0535 mL	0.2674 mL	0.5348 mL	1.3370 mL
	50 mM	0.0428 mL	0.2139 mL	0.4279 mL	1.0696 mL
	60 mM	0.0357 mL	0.1783 mL	0.3565 mL	0.8914 mL
	80 mM	0.0267 mL	0.1337 mL	0.2674 mL	0.6685 mL
	100 mM	0.0214 mL	0.1070 mL	0.2139 mL	0.5348 mL

ON1231320 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ON12313201312471-39-8ON 1231320ON-1231320MitosisPolo-like Kinase (PLK)ApoptosisG2/MphasemitosisfibroblastsU2OSMDAMB-231triplenegativebreastInhibitorinhibitorinhibit

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ON1231320

고객리뷰

Other Forms of ON1231320:

ON1231320 Related Antibodies

2 Publications Citing Use of MCE ON1231320

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Biological Activity

순도&문서

References

고객리뷰

ON1231320 Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

ON1231320 Related Classifications

Keywords:

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고객리뷰

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