2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. Phospholipase A2

ホスホリパーゼA2  (Synonyms: Phospholipase A2; PLA2)

製品番号: HY-P3029
COA 取扱説明書 Technical Support

Phospholipase A2 (PLA2) is a calcium-dependent, heat-stable enzyme that catalyzes the hydrolysis of glycerophospholipids at the sn-2 position of cellular membranes, thereby releasing Arachidonic Acid (AA) (HY-109590). Phospholipase A2 is a key mediator in the biosynthesis of pro-inflammatory lipid mediators, critically involved in inflammatory processes. Phospholipase A2 can be used for cardiovascular and inflammatory diseases research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Phospholipase A2

ホスホリパーゼA2 構造式

CAS 番号 : 9001-84-7

容量 価格（税別） 在庫状況 数量
1 mg $62 在庫あり
5 mg $180 在庫あり
10 mg   お問い合わせ  
50 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

Other Forms of Phospholipase A2:

ホスホリパーゼA2 関連抗体

Top Publications Citing Use of Products

Phospholipase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Phospholipase A PLD Phospholipase C

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Phospholipase A2 (PLA2) is a calcium-dependent, heat-stable enzyme that catalyzes the hydrolysis of glycerophospholipids at the sn-2 position of cellular membranes, thereby releasing Arachidonic Acid (AA) (HY-109590). Phospholipase A2 is a key mediator in the biosynthesis of pro-inflammatory lipid mediators, critically involved in inflammatory processes. Phospholipase A2 can be used for cardiovascular and inflammatory diseases research[1][2][3][4].

体外実験

Phospholipase A2-modified apoB-100 lipoproteins, which are more susceptible to further enzymatic and nonenzymatic modifications, induce accumulation of intracellular lipids in macrophages and bind strongly to extracellular matrix proteoglycans[2].
Phospholipase A2 can induce aggregation and fusion of the matrix-bound lipoproteins and so further increase their binding strength to the matrix proteoglycans[2].
Phospholipase A2 can modify the circulating lipoproteins and so induce formation of small dense LDL particles, which are associated with increased risk for cardiovascular disease[2].
Phospholipase A2 injures lymphatic endothelial cells leading to progression of secondary lymphoedema[3].
Phospholipases A2 can be used for the synthesis of prostaglandins, leukotrienes, platelet-activating factors, and other bioactive lipids[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ホスホリパーゼA2 関連抗体
臨床実験
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

[Phospholipase A2]
EC Number

3.1.1.4
Enzyme Activity

≥10 U/mL
Unit Definition

One unit is defined as the amount of enzyme that will hydrolyze 1.0 μmole of soybean L-αphosphatidylcholine to L-α-lysophosphatidylcholine and afatty acid per min at pH 8.0 at 37°C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
溶剤 & 溶解度
体外: 

H2O : ≥ 25 mg/mL

*"≥" means soluble, but saturation unknown.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

COA (242 KB)

取扱説明書 (2659 KB)
参考文献
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Phospholipase A2 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phospholipase A29001-84-7PLA2Phospholipase A 2Phospholipase A-2PLA 2PLA-2Phospholipasesn-2arachidonic acidcalcium-dependentInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
Phospholipase A2
製品番号:
HY-P3029
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.