2. Immunology/Inflammation Antibody-drug Conjugate/ADC Related
  3. Transmembrane Glycoprotein ADC Antibody
  4. Polatuzumab

Polatuzumab is a monoclonal antibody that targets CD79b on the surface of B cells. Polatuzumab can be used to synthesize the ADC Polatuzumab Vedotin (HY-132253), which has anti-tumor activity.

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CAS No. : 2279068-37-8

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Polatuzumab Related Antibodies

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2 Publications Citing Use of MCE Polatuzumab

  • Activité biologique

  • Pureté et documentation

  • Références

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Description

Polatuzumab is a monoclonal antibody that targets CD79b on the surface of B cells. Polatuzumab can be used to synthesize the ADC Polatuzumab Vedotin (HY-132253), which has anti-tumor activity[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

CD79B
In Vitro

Polatuzumab Vedotin is composed of a humanized anti-CD79b monoclonal antibody linked to the synthetic microtubule-disrupting agent MMAE (HY-15162) via a cleavable peptide linker, and it can be used in the research of diffuse large B-cell lymphoma (DLBCL)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Polatuzumab Related Antibodies
Essai clinique
Gene ID

974  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Masse moléculaire

145.5 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Polatuzumab]
Livraison

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Flow Cytometry analysis of Raji cells labelling CD79B (red) with Polatuzumab (anti-CD79B) (HY-P99042). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.
  • Immobilized CD79B Protein, Human (HY-P70541) can bind Polatuzumab, with the EC50 is 1.037 ng/mL.
Pureté et documentation

Purity: 99.69%

SDS (251 KB)

COA (232 KB) SDS-PAGE (172 KB) SEC-HPLC (264 KB)

Inhibitory Antibodies User Guide (603 KB)
Références
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Polatuzumab Related Classifications

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  • Calculateur de dilution

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Polatuzumab2279068-37-8Transmembrane GlycoproteinADC Antibodymonoclonal antibodytargets CD79bADCDLBCLInhibitorinhibitorinhibit

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HY-P99042
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SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Korean - KR (251 KB) Portuguese - PT (251 KB)

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