CD79B - CD79b molecule Gene

Homo sapiens

Also known as B29; IGB; AGM6; Igbeta

Gene ID: 974 | Gene type: protein coding

About CD79B

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,928,740-63,932,331 (from NCBI)

This gene has 7 transcripts (splice variants), 131 orthologues, 1 paralogue and is associated with 71 phenotypes. Biased expression in lymph node (RPKM 118.7), spleen (RPKM 71.5) and 3 other tissues.

Summary

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

CD79B Products(4)

mRNA	Protein	Name
NM_000626.4	NP_000617.1	B-cell antigen receptor complex-associated protein beta chain isoform 1 precursor
NM_001039933.3	NP_001035022.1	B-cell antigen receptor complex-associated protein beta chain isoform 3 precursor
NM_001329050.2	NP_001315979.1	B-cell antigen receptor complex-associated protein beta chain isoform 4 precursor
NM_021602.4	NP_067613.1	B-cell antigen receptor complex-associated protein beta chain isoform 2 precursor

CD79B Protein Structure

V-set

ITAM

0
100
200
230 a.a.

Protein Preferred Names

Protein Names

B-cell antigen receptor complex-associated protein beta chain

B-cell-specific glycoprotein B29

Recombinant CD79B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70541	CD79B Protein, Human (HEK293, His)	P40259 (A29-D159)	≥95%
HY-P70768	CD79B Protein, Human (Biotinylated, HEK293, His-Avi)	P40259 (A29-D159)	≥95%
HY-P75386	CD79 Protein, Human (HEK293, Flag-His)	P11912 (L33-R143)&P40259 (A29-D159)	≥95%
HY-P78415	CD79B Protein, Human (HEK293, His-Avi)	P40259 (A29-D159)	≥95%

Related Diseases

Diseases

Alias

Agammaglobulinemia 6, Autosomal Recessive

Agammaglobulinemia 6	AGM6
Agammaglobulinemia, Autosomal Recessive, Due To Cd79b Defect	Agammaglobulinemia Autosomal Recessive Due To Cd79b Defect
Agammaglobulinemia, Type 6, Autosomal Recessive

Agammaglobulinemia, Non-Bruton Type

Autosomal Agammaglobulinemia

Agammaglobulinemia

Hypogammaglobulinemia	Ighm
Mu Heavy Chain Deficiency	Mu-Heavy Chain Disease
Mu-Hcd	Mu-Chain Disease

Mcd Diffuse Large B-Cell Lymphoma

Mcd Dlbcl

Doid:0081066

Bn2 Diffuse Large B-Cell Lymphoma

Bn2 Dlbcl

Doid:0081064

Testicular Lymphoma

Malignant Lymphoma Of Testis

Lymphoma Of The Testis

Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Central Nervous System Hematologic Cancer

Cns Hematopoietic Tumor	Hematopoietic Neoplasm Of Central Nervous System
Central Nervous System Hematopoietic Neoplasm

Central Nervous System Lymphoma

Microglioma	Primary Cns Lymphoma
Cns Lymphoma	Primary Central Nervous System Lymphoma

Lambda 5 Deficiency

Agammaglobulinemia 4, Autosomal Recessive

Agammaglobulinemia 4	AGM4
Agammaglobulinemia, Autosomal Recessive, Due To Blnk Defect	B Cell Linker Protein Deficiency
B-Cell Linker Protein Deficiency	Blnk Deficiency
Agammaglobulinemia Autosomal Recessive Due To Blnk Defect	Agammaglobulinemia, Type 4, Autosomal Recessive

B-Cell Prolymphocytic Leukemia

B Cell Prolymphocytic Leukemia	Prolymphocytic Leukemia, B-Cell Type
B-Pll	Doid:0081041
Leukemia, Prolymphocytic, B-Cell	Pll- [Prolymphocytic Leukaemia]
Prolymphocytic Leukaemia	Prolymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission

Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Cll/Sll	B-Cell Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Icdo:9823/3	Chronic Lymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission
Small Cell B-Cell Lymphoma

Primary Mediastinal B-Cell Lymphoma

Large Cell Lymphoma Of The Mediastinum	Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis
Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type

Lymphoplasmacytic Lymphoma

Waldenstrom Macroglobulinemia	Malignant Lymphoma - Lymphoplasmacytic
Waldenström Macroglobulinaemia	Waldenström Macroglobulinaemia Without Mention Of Remission
Idiopathic Macroglobulinaemia	Primary Macroglobulinaemia

Spleen Cancer

Spleen Neoplasm	Splenic Neoplasm
Splenic Neoplasms	Malignant Splenic Tumor
Malignant Tumour Of Spleen	Tumor Of Spleen
Malignant Neoplasm Of Spleen

High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit

Hgbl-Dh/Th	High Grade B-Cell Lymphoma With Myc And Bcl2 Or Bcl6 Rearrangements
High Grade B-Cell Lymphoma With Myc And/ Or Bcl2 And/Or Bcl6 Rearrangement

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Splenic Marginal Zone Lymphoma

Smzl	Splenic Marginal Zone B-Cell Lymphoma

Ezb Diffuse Large B-Cell Lymphoma

Ezb Dlbcl

Doid:0081065

Plasmacytoma

Solitary Plasmacytoma	Solitary Myeloma
Myeloma - Solitary	Myeloma, Solitary
Plasmacytoma - Category	Solitary Osseous Plasmacytoma
Solitary Plasmacytoma Without Mention Of Remission	Localised Malignant Plasma Cell Tumour Nos
Plasmacytoma Nos

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Richter'S Syndrome

Richter Syndrome

Richter Transformation

Marginal Zone B-Cell Lymphoma

Marginal Zone Lymphoma	Mzl
Mucosa-Associated Lymphoid Tissue Lymphoma

Eye Lymphoma

Malignant Lymphoma Of Eye

Lymphoma Of Eye

Cerebral Lymphoma

Primary Cerebral Lymphoma	Brain Primary Lymphoma
Primary Lymphoma Of Cerebrum

Ecthyma

Adult Lymphoma

Agammaglobulinemia, X-Linked

X-Linked Agammaglobulinemia	XLA
Bruton Type Agammaglobulinemia	Bruton'S Agammaglobulinemia
Bruton-Type Agammaglobulinemia	Agmx1
Imd1	Agammaglobulinemia, X-Linked 1
Btk-Deficiency	Agammaglobulinemia
Hypogammaglobulinemia	Agammaglobulinemia, X-Linked, Type 1
Immunodeficiency 1	Bruton Agammaglobulinemia Tyrosine Kinase Deficiency
Bruton Disease	Bruton'S Agammaglobulinaemia
Bruton'S Sex-Linked Agammaglobulinemia	Bruton'S Type Agammaglobulinemia
Btk Deficiency	Agammaglobulinemia, Btk
Agammaglobulinemia, Bruton Tyrosine Kinase	Congenital Agammaglobulinemia
Immunodeficiency Type 1	X-Linked Agammaglobulinemia Type 1

Plasma Protein Metabolism Disease

Diffuse Large B-Cell Lymphoma Activated B-Cell Type

Dlbcl Abc Type

Waldenstroem'S Macroglobulinemia

Waldenstrom Macroglobulinemia	Macroglobulinemia Of Waldenstrom
Waldenström Macroglobulinemia	Lymphoplasmacytic Lymphoma With Igm Gammopathy
Lymphoplasmacytic Lymphoma	Waldenstrom'S Macroglobulinaemia
Waldenstrom'S Syndrome	Waldenstrom'S Macroglobulinemia
Wm	Waldenström'S Macroglobulinemia
Malignant Lymphoma - Lymphoplasmacytic

Mantle Cell Lymphoma

Lymphoma, Mantle Cell	Lcm
Mcl	Mantle Zone Lymphoma
Lymphoma Mantle-Cell	Lymphoma, Mantle-Cell
Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse	Malignant Lymphoma - Lymphocytic, Intermediate Differentiation
Diffuse Small Cleaved-Cell Lymphoma	Diffuse Small Cleaved Cell Malignant Lymphoma
Small Cleaved Cell Non-Hodgkin Lymphoma	Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma
Malignant Lymphomatous Polyposis	Malignant Small Cell, Noncleaved, Diffuse Lymphoma
Malignant Undifferentiated Cell, Non-Burkitt Lymphoma	Cleaved Cell Lymphoma
Small Cell Mantle Cell Lymphoma	Small Cleaved Cell Malignant Lymphoma

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma	Gastric Lymphoma, Primary
Lymphoma, Malt, Somatic	Mucosa-Associated Lymphoid Tissue Lymphoma
Extranodal Marginal Zone B-Cell Lymphoma	MALTOMA
Marginal Zone B-Cell Lymphoma	Mucosa-Associated Lymphatic Tissue Lymphoma
Primary Gastric Lymphoma	Gastric Lymphoma
Familial Primary Gastric Lymphoma

Mature B-Cell Neoplasm

Mature B-Cell Lymphocytic Neoplasm	Neoplasm Of Mature B-Cells
Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma	Lymphoma, Non-Hodgkin
NHL	Lymphoma, Non-Hodgkin, Somatic
Lymphoma, Follicular, Somatic	Familial Non-Hodgkin Lymphoma
Lymphoma Non-Hodgkins	Follicular Lymphoma, Somatic
Lymphosarcoma	Non-Hodgkins Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132253	Polatuzumab vedotin		98.87%	Phase 3
HY-P99042	Polatuzumab		99.69%	Phase 3

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163295	BTK degrader-1	Degrader	/	Unkown
HY-RS02268	CD79B Human Pre-designed siRNA Set A		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99656	Iladatuzumab		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CD79B	VGNC	VGNC:27047
Mus musculus	CD79B	MGD	MGI:96431
Canis familiaris	CD79B	VGNC	VGNC:38974
Macaca mulatta	CD79B	VGNC	VGNC:99136
Rattus norvegicus	CD79B	RGD	RGD:620012
Others	CD79B	NCBI