CD79b Antibody (YA3995)(PBS only)
(Synonyms: B29; IGB; AGM6)CD79b Antibody (YA3995) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD79b.
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Host:
Mouse
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Isotype:
IgG1
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Application:
ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:25-1:50 | 1:200-1:400 | 1:10000 |
Product Details
CD79b Antibody (YA3995) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD79b.
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Host Mouse
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 30-50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 26 kDa
Purified recombinant fragment of human CD79B (AA:extra 30-160) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD79b is required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:B cells -
Isoforms & Post-Translational Modification
P40259 has 3 isomers: P40259-1: 26048 Da (predicted); P40259-2: 14030 Da (predicted); P40259-3: 26119 Da (predicted).
Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK -
Subunit
Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen-specific membrane-bound surface immunoglobulin of two heavy chains and two light chains (PubMed:35981043).
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SwissProt ID
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Synonyms
B29; IGB; AGM6
Documentation
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