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Cat. No.: HY-132253

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Polatuzumab vedotin

1 Cited Publications

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Polatuzumab vedotin is an antibody-drug conjugate targeting CD79b. It contains a humanized anti-CD79b IgG1 monoclonal antibody linked to monomethyl auristatin E (MMAE), a potent microtubule inhibitor. The antibody portion is Polatuzumab (HY-P99042), and the drug-linker conjugate for ADC is VcMMAE (HY-15575). Polatuzumab vedotin has the potential for the research of Large B-cell lymphomas (LBCL).

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Pureté: 99.37%
CAS No.: 1313206-42-6
Masse moléculaire:150000 (average)

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Polatuzumab vedotin Chemical Structure

CAS No.: 1313206-42-6

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Activité biologique

Description

In Vivo

Polatuzumab vedotin (0.3, 1, 3, 6, 12 mg/kg; i.v.; once) shows anti-tumor in a mouse tumour xenograft model of human diffuse large B-cell lymphoma WSU-DLCL2^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SCID mice (human diffuse large B-cell lymphoma WSU-DLCL2)^[2]
Dosage:

0.3, 1, 3, 6, 12 mg/kg
Administration:

I.v.; once
Result:

Showed dose-dependent tumour growth inhibition.

Chemical Information

CAS No. 1313206-42-6
Appearance Solid
Masse moléculaire 150000 (average)
Color White to off-white
SMILES

[Polatuzumab vedotin]
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Shipping with dry ice.
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Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Anal Chem

Direct Visualization and Quantitative Modeling of Mass Transport Limitation in Biomolecular Kinetics via Imaging-Based Meta-SPR. [Abstract]

2026 Mar 24;98(11):8382-8393. PMID: 41814478

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (257 KB)
SDS (251 KB)
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- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Liebers N, et al. Polatuzumab vedotin as a salvage and bridging treatment in relapsed or refractory large B-cell lymphomas. Blood Adv. 2021 Jul 13;5(13):2707-2716. [Content Brief]

[2]. Li D, et al. Evaluation and use of an anti-cynomolgus monkey CD79b surrogate antibody-drug conjugate to enable clinical development of polatuzumab vedotin. Br J Pharmacol. 2019 Oct;176(19):3805-3818. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Polatuzumab vedotin

1 Cited Publications

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Activité biologique
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Publications (1)
Pureté et documentation
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Polatuzumab vedotin

Publications Citing Use of MedChemExpress (MCE) Polatuzumab vedotin

Activité biologique

Chemical Information

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Polatuzumab vedotin Related Classifications

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