MGD010  (Synonyms: PRV-3279)

MGD010 (PRV-3279) is a bispecific antibody targeting CD32B (FcγRIIb) and CD79B. MGD010 transmits negative signals by simultaneously co-linking CD32B (FcγRIIb) with CD79B, a component of the B-cell receptor (BCR), thereby inhibiting activated B cells. MGD010 can be used in research related to autoimmune diseases^[1][2].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Human

CD79b & Fc-gamma-R2B

MGD010 specifically binds to two key molecules on the surface of B cells simultaneously: CD32B and CD79B, thereby inhibiting the function of activated B cells without depleting them^[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

974  [NCBI] & 2213  [NCBI]

P40259 & P31994

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

108.77 kDa

Liquid

Colorless to light yellow

N/A

Shipping with dry ice.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  Immobilized Human CD79B Protein, His Tag can bind MGD010. The EC₅₀ for this effect is 230.9 ng/mL.
• 
  Loaded MGD010 on ProA biosensor, can bind Human CD32b/c Protein, His Tag with an affinity constant of 1.15E-08 M as determined in BLI assay.

• [1]. Chen W, Shankar S, Lohr JA, Yao XT, Li H, Chen X, Muth J, Gal-Edd N, Bonvini E, Johnson S, Pandya N. SAT0027 Immunomodulatory effects of MGD010, a dart® molecule targeting human B-CELL CD32B and CD79B. Annals of the Rheumatic Diseases. 2017 Jun 1;76:777-8.
  

  [2]. Pandya, N., et al. OP0201 Safety, Tolerability, and Functional Activity of MGD010, A Dart® Molecule Targeting CD32B and CD79B, Following A Single Dose Administration in Healthy Volunteers. Annals of the Rheumatic Diseases, 2016. 75(Suppl 2), 132.3-133.