Polyinosinic acid 

Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) ligand. Polyinosinic acid enhances cellular immune response through TLR3 and TRIF. Polyinosinic acid has potential applications in immune regulation^[1].

Polyinosinic acid (50 µg/mL, 24 h) induces the expression of CD86, CD40 and MHC II in BALB/c B cells, the expression of CD86 and CD40 in BALB/c BMDC cells^[1].
Polyinosinic acid (1-25 µg/mL, 48 h) enhances the uptake of [³H] thymidine by BALB/c B cells in a dose dependent manner^[1].
Polyinosinic acid (50 µg/mL, 20 h) induces BALB/c BMDC cells, macrophages to secrete TNFα and IL-12, and BALB/c B cells, BMDC cells to secrete IFN. Polyinosinic acid increases expression of MHC II, CD86 in C57Bl/6, MyD88 knockout and TLR4 knockout mouse B cells^[1].
Polyinosinic acid (50 µg/mL, 48 h) increases the uptake of thymidine by C57Bl/6, MyD88 knockout and TLR4 knockout mouse B cells^[1].
Polyinosinic acid (25 µg/mL and 50 µg/mL, 24 h) induces BEAS-2B cells secrete IP-10 with dose-dependent manner^[1].
Polyinosinic acid (50 µg/mL, 24-48 h) regulates the expression of CD86 and thymidine uptake in B cells of TRIF⁺/⁺ and TRIF^-/^- mice through TRIF^[1].
Polyinosinic acid (10-50 µg/mL, 20 h) increases BMDC cells derived from TLR3⁺/⁺ to secrete IFN and IFNα without affecting BMDC cells derived from TLR3^-/^-[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(C₁₀H₁₃N₄O₈P)x

30918-54-8

O=P(O)(O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=C(C(N=CN3)=O)N=C2)O1.[x]

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• [1]. Marshall-Clarke S, et al. Polyinosinic acid is a ligand for toll-like receptor 3. J Biol Chem. 2007 Aug 24;282(34):24759-66.  [Content Brief]